• Anthony J. Chambers
  • Janice L. Pasieka
Part of the Cancer Treatment and Research book series (CTAR, volume 153)


Gastrinomas are uncommon tumors of the endocrine system, occurring within the pancreas and duodenum. Overproduction of the hormone gastrin by these tumors produces a sustained increase in gastric acid secretion, leading to complications of peptic ulceration known as the Zollinger–Ellison syndrome (ZES). Furthermore, gastrinomas have the potential to metastasize to regional lymph nodes, the liver and to other distant sites, and it is this malignant potential which has become increasingly important since the introduction of effective medical therapy to control gastric acid secretion. Gastrinomas can occur sporadically or in a familial pattern as a component of the multiple endocrine neoplasia type I (MEN1) syndrome. Given that the endocrinopathy associated with these tumors can be well controlled medically, the role of surgical resection in the setting of advanced disease and in patients with MEN1 syndrome is the subject of continued debate.


Neuroendocrine Tumor Hepatic Metastasis Gastric Acid Secretion Gastrin Level Gastric Inhibitory Polypeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of Calgary and Tom Baker Cancer CentreCalgaryCanada

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