Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters

  • Rommel G. Tirona


Nuclear receptors play a central role on the mechanism of induction-type drug–drug interactions by acting as xenosensing transcription factors. Together, PXR, CAR, FXR, and VDR form a core group of nuclear receptors that regulate the expression of a number of important drug-metabolizing enzymes and drug transporters. In this chapter, the molecular determinants of adaptive response to drug exposure are detailed in the context of clinical relevance and drug development.


Nuclear Receptor Constitutive Androstane Receptor Primary Human Hepatocyte Cerebrotendinous Xanthomatosis Human Immunodeficiency Virus Protease Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Clinical Pharmacology, Department of Medicine, Department of Physiology & PharmacologySchulich School of Medicine and Dentisity, University of Western Ontario, London Health Sciences Centre - University HospitalLondonCanada

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