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The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans

  • Jashvant D. Unadkat
  • Brian J. Kirby
  • Christopher J. Endres
  • Joseph K. Zolnerciks
Chapter

Abstract

Drug transport proteins have been recognized as significant contributors to drug absorption, distribution, elimination, toxicity, and efficacy. This chapter will discuss the key concepts of transporter-based drug–drug interactions (DDIs), provide a concise review of DDIs involving the major drug transporters, and describe methodologies used to quantitatively predict the magnitude of transporter-based DDIs in humans.

Keywords

Breast Cancer Resistance Protein Canalicular Membrane Biliary Clearance Equilibrative Transporter Efflux Clearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by NIH grants GM032165 and GM54447. Brian Kirby was supported in part by an ARCS fellowship and an NIH Pharmacological Sciences training grant (GM07550).

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jashvant D. Unadkat
    • 1
  • Brian J. Kirby
    • 2
  • Christopher J. Endres
    • 2
  • Joseph K. Zolnerciks
    • 2
  1. 1.Department of Pharmaceutics, School of PharmacyUniversity of WashingtonSeattleUSA
  2. 2.Department of PharmaceuticsUniversity of WashingtonSeattleUSA

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