Management of Drug Interactions of New Drugs in Multicenter Trials Using the Metabolism and Transport Drug Interaction Database©
The Metabolism and Transport Drug Interaction Database© (DIDB) is a web-based research tool (http://www.druginteractioninfo.org) for scientists and clinicians working in the field of drug interactions (DIs). The DIDB enables users to access, manage, and analyze the scientific basis of clinical drug interactions for drugs, biologics, food, and herbal derivatives. Users can search the database using a number of queries that allow them to approach the data from different perspectives. This chapter illustrates how the DIDB can be used by clinical investigators to manage drug interactions of new molecular entities in the context of a disease and its comorbidities or during multicenter trials.
KeywordsCYP3A Inhibitor Drug Interaction Potential Sensitive Substrate Strong CYP3A Inhibitor Drug Interaction Profile
- Drugs@FDA: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/ (accessed Apr 2009)
- FDA Guidance for Industry: Drug Interaction Studies – Study Design, Data Analysis, and Implications for Dosing and Labeling. Draft guidance (Released September 2006). Available at: http://www.fda.gov/cder/guidance/6695dft.htm (accessed Apr 2009)
- Hachad H, Ragueneau-Majlessi I and Levy RH. Metabolism and transport drug interaction database: a web-based research and analysis tool, in Drug–Drug Interactions Second Edition (David Rodrigues A ed), pp 567–579, Informa Healthcare, New York (2008).Google Scholar
- PubMed: http://www.ncbi.nlm.nih.gov/sites/entrez (accessed Apr 2009)