Tetraspanins in Cancer
The Tetraspanins comprise a distinct family of small transmembrane proteins capable of molecular organization of its non-tetraspanin partners. The 33 family members are characterized by a recurrent structural theme and conserved cysteines. While catalytic domains and ligands have not been identified, tetraspanins appear to function as molecular organizers by recruiting non-tetraspanin partners into organized membrane structures known as tetraspanin-enriched microdomains (TERM). These interactions allow tetraspanins to regulate adhesion, cytoskeletal interactions, molecular signaling, and protein trafficking. Tetraspanins are involved in a multitude of biological processes ranging from synaptic contacts at neuromuscular junctions to epithelial integrity and T-cell activation. In recent years, their role in several malignancies has become particularly apparent. Some tetraspanins appear capable of limiting cancer progression while others promote tumor growth, invasion, and metastasis. This chapter focuses on reviewing the current understanding of tetraspanins in tumorigenesis.
KeywordsTetraspanin Cancer Migration Tetraspanin Enriched Microdomain (TERM) TSPAN TM4SF Scaffold
This work was supported, in part, by -5K01 CA120711-02 (NIH/NCI).
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