Computational Tools and Resources for Systems Biology Approaches in Cancer
Systems biology focuses on the study of interacting components of biological systems rather than on the analysis of single genes or proteins and offers a new approach to understand complex disease mechanisms by the use of computational models. The analysis of such models has become crucial to understand biological processes and their dysfunctions with respect to human diseases. A systems biology approach would be a key step in improving diagnosis and therapy of complex diseases such as cancer. It offers new perspectives for drug development, for example, in detecting drug side effects and alternative response mechanisms through the analysis of large cellular networks in silico.
In this chapter we review important cellular processes for cancer onset, progression, and response to anticancer drugs, provide a summary of existing pathway databases and tools for the construction and analysis of computational models, and discuss existing kinetic models for cancer-related signaling pathways.
KeywordsNerve Growth Factor Pathway Database System Biology Markup Language Molecular Interaction Network BioModels Database
This work was supported by the EU FP6 grant SysCo (LSHG-CT-2006–37231), the Mutanom project (01GS08105) supported by the German Federal Ministry of Education and Research (BMBF) and the Max Planck Society.
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