HIV Co-receptors: The Brain Perspective



Chemokines and chemokine receptors are significant to the establishment and maintenance of HIV-1 infection, viral transmission, and AIDS pathogenesis. They also play an important role in the development of neurologic complications of AIDS, including HIV-1-associated dementia (HIVD), through several mechanisms. The contribution of chemokines to the development of AIDS and HIVD is complex; some chemokines appear to aid pathogenesis, while others appear to be protective. In the following chapter, we discuss the role of chemokines and chemokine receptors in HIV-1 infection and the pathogenesis of AIDS and HIVD. Potential therapeutic strategies are also briefly detailed.


Chemokine Receptor Kawasaki Disease Progressive Multifocal Leukoencephalopathy Tropic Virus Central Nervous System Compartment 
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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of NeuroscienceTemple University School of MedicinePhiladelphiaUSA

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