Salivary Gland and Adnexal Type Tumors of the Lungs

  • Annikka Weissferdt
  • Cesar A. Moran


Salivary gland type tumors have been described in many locations of the body including the bronchopulmonary system. In the lungs, they are thought to arise from the minor salivary gland tissue of the tracheobronchial tree. Morphologically, histochemically, and immunohistochemically, these tumors share similar characteristics with their counterparts in the salivary glands; however, some differences have been observed in their histologic spectrum and biologic behavior. In addition, contrary to primary salivary gland tumors, the tumors arising in the lungs are uncommon, representing <1 % of all pulmonary neoplasms [1, 2]. Therefore, careful clinical and radiological investigations in patients presenting with a pulmonary salivary gland type tumor are essential to rule out metastasis from a salivary gland primary. The salivary gland type tumors known to originate in the lungs include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, pleomorphic adenoma, carcinoma ex pleomorphic adenoma, epithelial-myoepithelial carcinoma, and oncocytoma. Another rare adnexal type neoplasm, sebaceous carcinoma, is also included in this chapter. The most pertinent histochemical, immunohistochemical, ultrastructural, and molecular features of these tumors are summarized in Table 6.1.


Salivary Gland Epidermal Growth Factor Receptor Mutation Myoepithelial Cell Adenoid Cystic Carcinoma Pleomorphic Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Annikka Weissferdt
    • 1
  • Cesar A. Moran
    • 1
  1. 1.Department of PathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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