Neuroendocrine Carcinomas

  • Annikka Weissferdt
  • Cesar A. Moran


Neuroendocrine neoplasms occurring primary in the lung account for approximately 15 % of this family of tumors. Unfortunately, the bulk of neuroendocrine tumors are made up by small cell lung carcinoma. In recent statistics, it has been estimated that small cell carcinomas of the lung may account for approximately 30,000 new cases on a yearly basis. Paradoxically, a disease that previously was observed predominantly in older men, now appears to affect men and women almost equally. However, it is important to keep in mind that although the gamut of primary lung tumors that may show neuroendocrine differentiation is rather complex, involving tumors not only of epithelial but also of mesenchymal or neural origin, this chapter will be limited to the most conventional epithelial carcinomas that range from the low- to the high-grade types. Another important aspect in this chapter this chapter will be the discussion with another neuroendocrine tumor that, even though not considered carcinoma, may pose a significant problem in the differential diagnosis: intrapulmonary paraganglioma.


Neuroendocrine Tumor Carcinoid Tumor Small Cell Carcinoma Mitotic Count Large Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Annikka Weissferdt
    • 1
  • Cesar A. Moran
    • 1
  1. 1.Department of PathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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