The Role of High Throughput Molecular Analysis of Biofluids and Tumors in Patients with Oral Cancer

  • Shen Hu
  • Zhanzhi Hu
  • Xiaofeng Zhou
  • David T. Wong


Oral cancer, predominantly oral squamous cell carcinoma, is considered as the 6th most common human cancer in the world. The American Cancer Society estimated that 35,310 new cases of oral cancer were diagnosed in 2008 and 7,590 patients died from the disease in the US. Worldwide, oral cancer is a major cancer problem, with an estimated 300,000 new cases diagnosed annually. Patients with OSCC are often diagnosed at a late stage, and there is a high recurrence rate after treatment, especially in those with neck lymph node metastasis. The overall 5-year survival rates for oral cancer have remained low and stagnant during the past few decades. The high mortality rate can be attributed to factors including nonresponsiveness to chemotherapy and radiation therapy, late presentation of the lesions, and the lack of biological markers for the early detection of these lesions. In this chapter, we have provided a brief introduction on current genomic and proteomic technologies and review their applications in molecular analysis of oral cancer. A precise molecular portrait of oral carcinogenesis will improve diagnosis, treatment, and monitoring of the disease.


Oral Cancer Comparative Genomic Hybridization Single Nucleotide Polymorphism Array Single Nucleotide Polymorphism Array Data Single Nucleotide Polymorphism Array Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Shen Hu
  • Zhanzhi Hu
  • Xiaofeng Zhou
  • David T. Wong
    • 1
    • 2
  1. 1.Dental Research Institute, Jonsson Comprehensive Cancer CenterSchool of DentistryLos AngelesUSA
  2. 2.Molecular Biology InstituteUniversity of California at Los AngelesLos AngelesUSA

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