Cancer Stem Cells and Oral Cavity Cancer Metastasis

  • Mark Prince


Oral cavity squamous cell carcinoma is a common malignancy with a high propensity for the development of metastasis. Even early stage oral cavity tumors are frequently associated with metastasis to regional lymph nodes. Cancer stem cells have recently been isolated from head and neck squamous cell cancer and represent the critical population of cancer cells responsible for primary tumor growth. Cancer stem cells also likely represent the population of cancer cells responsible for resistance to therapy and regional and distant metastasis. The identification of this critical subpopulation of cancer cells will increase our ability to understand the mechanisms that which underlie the development of metastasis in head and neck cancer and holds promise for the development of new and more effective therapies for this devastating disease.


Cancer Stem Cell Adult Stem Cell Stem Cell Niche Normal Stem Cell Stem Cell Maintenance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Victoria Prince for help in creating the Metastasis Model figure.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Mark Prince
    • 1
  1. 1.A. Alfred Taubman Health Care CenterAnn ArborUSA

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