Site-Directed Therapy for Lung Cancer Metastases

  • Kevin S Oh
  • Baskaran Sundaram
  • Venkataramu Krishnamurthy
  • Allan Pickens
  • Malini Venkatram
  • Ella A Kazerooni
  • Charlie Pan
  • James Hayman


At the time of diagnosis, 40% of patients with non-small cell lung cancer (NSCLC) and nearly 70% of patients with small cell lung cancer (SCLC) have advanced metastatic disease. The prognosis of patients with advanced lung cancer is dismal, with a 5-year overall survival rate of 1–2%. The primary treatment of advanced disease is supportive care and palliative chemotherapy. However, there is a growing body of evidence suggesting that highly selected patients with oligometastatic disease can achieve long-term survival with ablative forms of site-directed therapy, including surgical resection, external beam radiation therapy (EBRT), stereotactic radiosurgery (SRS), stereotactic body radiation therapy (SBRT), and radiofrequency ablation (RFA). This chapter summarizes the experience with site-directed therapy in the management of metastatic lung cancer in the most commonly involved sites: brain, adrenal gland, liver, lung, and bone.


Liver Metastasis Brain Metastasis Small Cell Lung Cancer Radiation Therapy Oncology Group Local Control Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Kevin S Oh
    • 1
  • Baskaran Sundaram
    • 2
  • Venkataramu Krishnamurthy
    • 2
  • Allan Pickens
    • 3
  • Malini Venkatram
    • 4
  • Ella A Kazerooni
    • 2
  • Charlie Pan
    • 5
  • James Hayman
    • 5
  1. 1.Department of Radiation OncologyMassachusetts General HospitalBostonUSA
  2. 2.Department of RadiologyUniversity of MichiganAnn ArborUSA
  3. 3.Section of Thoracic Surgery, Department of SurgeryUniversity of MichiganAnn ArborUSA
  4. 4.Department of Internal MedicineSinai-Grace/Wayne State UniversityDetroitUSA
  5. 5.Department of Radiation OncologyUniversity of MichiganAnn ArborUSA

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