Experimental Animal Models for Studying Lung Cancer

  • Jiang Liu
  • Michael R. Johnston


Lung cancer is the leading cause of cancer-related mortality for both men and women worldwide. The use of animal models of lung cancer is necessary to improve our understanding of lung tumor biology and facilitate novel therapies and diagnostics. To this end, animal models should mimic both the genetic alterations found in human lung tumors and their histological characteristics. Currently, several types of animal models are widely used for experimental lung cancer research. These include chemically induced lung tumors, transgenic mouse models, and human tumor xenografts. A single model system that faithfully recaptures the entire spectrum of lung cancer biology is unlikely to exist. Different models that accurately reflect the various aspects of the disease are necessary to properly investigate such a complex disease. Tumorigenesis, proliferation, invasion, angiogenesis, metastasis, prevention, and therapy are all areas where specific models are required to ensure proper experimental design.

The purpose of this chapter is to summarize the various lung cancer model systems in use today and define both their utility and limitations. We will briefly describe all of these models and provide a more detailed description of the orthotopic lung cancer xenograft models.


Lung Cancer Lung Tumor Human Lung Cancer Human Tumor Xenograft Orthotopic Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Applied Molecular Oncology, Princess Margaret HospitalUniversity Health NetworkTorontoCanada
  2. 2.Division of Thoracic Surgery, Department of SurgeryDalhousie UniversityHalifaxCanada

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