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Role of Biomarkers in Personalized Medicine

  • Kewal K. Jain
Chapter

Abstract

A biological marker (biomarker) is simply a molecule that indicates an alteration in physiology from the normal. For example, any specific molecular alteration of a cancer cell either on DNA, RNA, or protein level can be referred to as a molecular marker. A biomarker is defined as a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. The topic of biomarkers has been discussed in a special report on this topic (Jain 2009f). The expression of a distinct gene can enable its identification in a tissue with none of the surrounding cells expressing the specific marker. Relation of biomarkers to other technologies and healthcare is shown in Fig. 3.1. Applications of biomarkers relevant to personalized medicine are: The biomarker would specifically and sensitively reflect a disease state and could be used for diagnosis, for predicting response to drug, and for disease monitoring during and following therapy. Biomarkers can be used as drug targets in drug development. Biomarkers might serve to integrate diagnostics and therapeutics.

Keywords

Personalized Medicine Pharmacogenetic Test Biopharmaceutical Industry Sodium Phenylbutyrate Pharmacogenomic Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Borovecki F, Lovrecic L, Zhou J et al (2005) Genome-wide expression profiling of human blood reveals biomarkers for Huntington’s disease. Proc Natl Acad Sci USA 102:11023–11028CrossRefPubMedGoogle Scholar
  2. Jain KK (2009f) Biomarkers: technologies, markets and companies. Jain PharmaBiotech, Basel, Switzerland.Google Scholar
  3. Kiernan UA (2008) Biomarker rediscovery in diagnostics. Expert Opin Mol Diagn 2:1391–1400CrossRefGoogle Scholar
  4. Maxwell PR, Flisiak R (2005) Changes in serological biomarkers of liver function and connective tissue turnover in chronic hepatitis B during lamivudine therapy. Biomarkers 10:475–84Google Scholar
  5. Miller WL, Hartman KA, Burritt MF et al (2005) Biomarker responses during and after treatment with nesiritide infusion in patients with decompensated chronic heart failure. Clin Chem 51:569–577CrossRefPubMedGoogle Scholar
  6. Riegman PH, Morente MM, Betsou F et al (2008) Biobanking for better healthcare. Mol Oncol 2:213–222CrossRefPubMedGoogle Scholar
  7. Stenvinkel P, Karimi M, Johansson S et al (2007) Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease? J Intern Med 261:488–499CrossRefPubMedGoogle Scholar
  8. Wunder A, Tung CH, Muller-Ladner U et al (2004) In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response. Arthritis Rheum 50:2459–2465CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Jain PharmaBiotechBaselSwitzerland

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