The Perceptual Effects of Chronic Retinal Stimulation

  • Alan Horsager
  • Ione Fine


Can functional vision be restored in blind human subjects using a microelectronic retinal prosthesis? The initial indications suggest that, yes, it is possible. However, the visual experience of these subjects is nothing like a digital scoreboard-like movie, with each electrode acting as an independent pixel. The work described here in this chapter suggests that there are interactions between pulses and across electrodes, at the electrical, retinal, or even cortical level that influence the quality of the percept. In particular, this work addresses the question, “how does the percept change as a function of pulse timing on single and multiple electrodes”? The motivation for the work described here is that these interactions must be understood and predictable if we are to develop a functional tool for blind human patients. In this chapter, we review work evaluating perceptual effects using chronic electric stimulation in three different implantable systems.


Optical Coherence Tomography Pulse Train Electrode Array Retinal Surface Reference Pulse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Alternative forced-choice


Age-related macular degeneration


Bare light perception




Direct stimulation


Intelligent medical implants


Intelligent retinal implant


Lateral geniculate nucleus


Light perception


Microphotodiode array


No light perception


Optical coherence tomography


Retinal degeneration 1


Retinitis pigmentosa


Retinal pigment epithelium-specific 65 kDa protein


Second Sight Medical Products, Inc.


Primary visual cortex


Visual processing unit


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Eos Neuroscience, Inc.Los AngelesUSA
  2. 2.Department of OphthalmologyUniversity of Southern CaliforniaLos AngelesUSA

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