The Neurobiology of Stress Throughout the Life Cycle

  • Jerald Kay


The study of stress is one of the most exciting areas within neurobiology and cognitive neuroscience. There has been a dramatic increase in scientific knowledge about physiological, anatomical, genetic, molecular, immunological, and psychological characteristics of adversity and its extraordinary ability to influence human development throughout the life cycle. Advances in the study of learning and memory, attachment, psychological trauma, and gene X environment interaction, to name a few, have created an increasingly sophisticated appreciation of biological, social, and psychological factors comprising the response to and impact of life’s challenges. This chapter will review recent contributions from studies among different fields and elucidate significant issues yet to be understood.


Post Traumatic Stress Disorder Stressful Life Event Serotonin Transporter Stress Hormone Implicit Memory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Ainsworth, M. D. S., Blechar, M. C., Waters, E., & Wall, S. (1978). Patterns of attachment: A psychological study of the strange situation. Hillside, MJ: Erlbaum.Google Scholar
  2. Barr, C. S., Newman, T. K., Shannon, C., Parker, C., Dvoskin, R. L., Becker, M. L., et al. (2004). Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biological Psychiatry, 55, 733–738.CrossRefPubMedGoogle Scholar
  3. Barton, D. A., Esler, M. D., Dawood, T., Lambert, E. A., Haikerwal, D., Brenchley, C., et al. (2008). Elevated brain serotonin turnover in patients with depression: Effect of genotype and therapy. Archives of General Psychiatry, 65, 38–46.CrossRefPubMedGoogle Scholar
  4. Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. American Journal of Psychiatry, 165, 969–977.CrossRefPubMedGoogle Scholar
  5. Born, J., Rasch, B., & Gais, S. (2006). Sleep to remember. Neuroscientist, 12, 410–424.CrossRefPubMedGoogle Scholar
  6. Bowlby, J. (1969). Attachment and Loss, Vol. 1 Attachment. London: Hogarth Press and Institute of Psycho-Analysis; New York: Basic BooksGoogle Scholar
  7. Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., et al. (2008). Influence of child abuse on adult depression: Moderation by the corticotropin-releasing hormone receptor gene. Archives of General Psychiatry, 65, 190–200.CrossRefPubMedGoogle Scholar
  8. Bremner, J. D., Randall, P., Scott, T. M., Bronen, R. A., Seibyl, J. P., Southwick, S. M.,et al. (1995). MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. American Journal of Psychiatry, 152, 973–981.PubMedGoogle Scholar
  9. Bremner, J. D., Randall, P. R., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C. M., et al. (1997). Hippocampal volume reduction in PTSD. Biological Psychiatry, 41, 23–32.CrossRefPubMedGoogle Scholar
  10. Carlson, E. A. (1998). A prospective longitudinal study of attachment disorganization/disorientation. Child Development, 69, 1107–1128.PubMedGoogle Scholar
  11. Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.CrossRefPubMedGoogle Scholar
  12. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.CrossRefPubMedGoogle Scholar
  13. Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry, 65, 409–415.CrossRefPubMedGoogle Scholar
  14. De Quervain, D. J., Kolassa, I. T., Ertl, V., Onyut, P. L., Neuner, F., Elbert, T., et al. (2007). A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience, 10, 1137–1139.CrossRefPubMedGoogle Scholar
  15. Dube, S. R., Anda, R. F., Felitti, V. J., Chapman, D. P., Williamson, D. F., & Giles, W. H. (2001). Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: Findings from the Adverse Childhood Experiences Study. The Journal of the American Medical Association, 286, 3089–3096.CrossRefGoogle Scholar
  16. Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A. M., Nordborg, C., Peterson, D. A., et al. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4, 1313–1317.CrossRefPubMedGoogle Scholar
  17. Essex, M. J., Klein, M. H., Cho, E., & Kalin, N. H. (2002). Maternal stress beginning in infancy may sensitize children to later stress exposure: effects on cortisol and behavior. Biological Psychiatry, 52, 776–784.CrossRefPubMedGoogle Scholar
  18. Fonagy, P. (2001). Attachment theory and psychoanalysis. New York: Other Press LLC.Google Scholar
  19. Fonagy, P. (2008). The mentalization-focused approach to social development. In F. N. Busch (Ed.), Mentalization: The theoretical considerations, research findings, and clinical implications (Vol. 29, pp. 3–43). New York: Taylor & Francis.Google Scholar
  20. Fonagy, P., & Target, M. (1997). Attachment and reflective function: Their role in self-organization. Development and Psychopathology, 9, 679–700.CrossRefPubMedGoogle Scholar
  21. Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999). Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science, 286, 1155–1158.CrossRefPubMedGoogle Scholar
  22. Frodl, T., Schule, C., Schmitt, G., Born, C., Baghai, T., Zill, P., et al. (2007). Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Archives of General Psychiatry, 64, 410–416.CrossRefPubMedGoogle Scholar
  23. Fuller-Thomson, E., & Brennenstuhl, S. (2009). Making a link between childhood physical abuse and cancer: results from a regional representative survey. Cancer, 115(14), 3341–3350.CrossRefPubMedGoogle Scholar
  24. Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., et al. (2008). Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychological Medicine, 4, 1–11.Google Scholar
  25. Gladstone, G. L., Parker, G. B., Mitchell, P. B., Malhi, G. S., Wilhelm, K., & Austin, M. P. (2004). Implications of childhood trauma for depressed women: an analysis of pathways from childhood sexual abuse to deliberate self-harm and revictimization. American Journal of Psychiatry, 161, 1417–1425.CrossRefPubMedGoogle Scholar
  26. Greenough, W. T. (1975). Experiential modification of the developing brain. American Scientist, 63, 37–46.PubMedGoogle Scholar
  27. Halligan, S. L., Herbert, J., Goodyer, I. M., & Murray, L. (2004). Exposure to postnatal depression predicts elevated cortisol in adolescent offspring. Biological Psychiatry, 55, 376–381.CrossRefPubMedGoogle Scholar
  28. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science, 297, 400–403.CrossRefPubMedGoogle Scholar
  29. Hayden, E. P., Dougherty, L. R., Maloney, B., Olino, T. M., Sheikh, H., Durbin, C. E., et al. (2008). Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism. Journal of Affective Disorders, 107, 227–230.CrossRefPubMedGoogle Scholar
  30. Heim, C., Newport, D. J., Heit, S., Graham, Y. P., Wilcox, M., Bonsall, R., et al. (2000). Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. The Journal of American Medical Association, 284, 592–597.CrossRefGoogle Scholar
  31. Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004). Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology, 29, 641–648.CrossRefPubMedGoogle Scholar
  32. Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., & Nemeroff, C. B. (2008). The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma. Biological Psychiatry, 63, 398–405.CrossRefPubMedGoogle Scholar
  33. Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008). The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology, 33, 693–710.CrossRefPubMedGoogle Scholar
  34. Holmes, A., Murphy, D. L., & Crawley, J. N. (2003). Abnormal behavioral phenotypes of serotonin transporter knockout mice: Parallels with human anxiety and depression. Biological Psychiatry, 54, 953–959.CrossRefPubMedGoogle Scholar
  35. Hu, H., Real, E., Takamiya, K., Kang, M. G., Ledoux, J., Huganir, R. L., et al. (2007). Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell, 131, 160–173.CrossRefPubMedGoogle Scholar
  36. Insel, T. R. (1997). A neurobiological basis of social attachment. American Journal of Psychiatry, 154, 726–735.PubMedGoogle Scholar
  37. Insel, T.R. (2008, July 7). Psychiatric NewsGoogle Scholar
  38. Ji, D., & Wilson, M. A. (2007). Coordinated memory replay in the visual cortex and hippocampus during sleep. Nature Neuroscience, 10, 100–107.CrossRefPubMedGoogle Scholar
  39. Kandel, E. R., & Schwartz, J. H. (1982). Molecular biology of learning: Modulation of transmitter release. Science, 218, 433–443.CrossRefPubMedGoogle Scholar
  40. Kay J. & Schwartz, V. (eds). The Textbook of College Mental Health. Chichester, England, John R. Wiley and Sons, in pressGoogle Scholar
  41. Kempermann, G. (2002). Why new neurons? Possible functions for adult hippocampal neurogenesis. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 22, 635–638.Google Scholar
  42. Kempermann, G., Gast, D., & Gage, F. H. (2002). Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Annals of Neurology, 52, 135–143.CrossRefPubMedGoogle Scholar
  43. Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry, 156, 837–841.PubMedGoogle Scholar
  44. Kendler, S., et al. (2005). The Interaction of Stressful Life Events and a Serotonin Transporter Polymorphism in the Prediction of Episodes of Major Depression: A Replication. Archives of General Psychiatry, 62, 529–535.CrossRefPubMedGoogle Scholar
  45. Kraemer, G. W., & Clarke, A. S. (1996). Social attachment, brain function, and aggression. Annuals of the New York Academy of Sciences, 794, 121–135.CrossRefGoogle Scholar
  46. LeDoux, J. (1996). The emotional brain: The mysterious underpinnings of emotional life. New York: Simon & Schuster.Google Scholar
  47. Lee, R., Geracioti, T. D., Kasckow, J. W., & Coccaro, E. F. (2005). Childhood trauma and personality disorder: Positive correlation with adult CSF corticotropin-releasing factor concentrations. American Journal of Psychiatry, 162, 995–997.CrossRefPubMedGoogle Scholar
  48. Lee, B. K., Glass, T. A., McAtee, M. J., Wand, G. S., Bandeen-Roche, K., Bolla, K. I., et al. (2007). Associations of salivary cortisol with cognitive function in the Baltimore memory study. Archives of General Psychiatry, 64, 810–818.CrossRefPubMedGoogle Scholar
  49. Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P., et al. (1998). Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature Neuroscience, 1, 69–73.CrossRefPubMedGoogle Scholar
  50. Lupien, S. J., McEwan, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the life span on the brain, behavior and cognition. Nature Reviews Neuroscience, 10, 434–445.CrossRefPubMedGoogle Scholar
  51. Lyons-Ruth, K. (1996). Attachment relationships among children with aggressive behavior problems: The role of disorganized early attachment patterns. Journal of Consulting and Clinical Psychology, 64, 64–73.CrossRefPubMedGoogle Scholar
  52. Lyons-Ruth, K. (1999). A relational diathesis model of hostile-helpless states of mind expression in mother-infant interaction. In J. Solomon & C. George (Eds.), Attachment disorganization (p. 44). New York: Guilford.Google Scholar
  53. Lyons-Ruth, K., Alpern, L., & Repacholi, B. (1993). Disorganized infant attachment classification and maternal psychosocial problems as predictors of hostile-aggressive behavior in the preschool classroom. Child Development, 64, 572–585.CrossRefPubMedGoogle Scholar
  54. Main, M., & Solomon, J. (1990). Procedures for identifying infants as disorganized/disoriented during the Ainsworth Strange Situation. In M. Greenberg, D. Ciccetti & E. M. Cummings (Eds.), Attachment during the preschool years: Theory, research, and intervention (pp. 121–160). Chicago, IL: University of Chicago Press.Google Scholar
  55. Malhotra, A. K., Kestler, L. J., Mazzanti, C., Bates, J. A., Goldberg, T., & Goldman, D. (2002). A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. American Journal of Psychiatry, 159, 652–654.CrossRefPubMedGoogle Scholar
  56. Martin, J.H. (1989). Neuroanatomy: Text and Atlas. Elsevier, New York.Google Scholar
  57. Masten, C. L., Guyer, A. E., Hodgdon, H. B., McClure, E. B., Charney, D. S., Ernst, M., et al. (2008). Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Child Abuse & Neglect, 32, 139–153.Google Scholar
  58. McCauley, J., Kern, D. E., Kolodner, K., Dill, L., Schroeder, A. F., DeChant, H. K., et al. (1997). Clinical characteristics of women with a history of childhood abuse: unhealed wounds. The Journal of the American Medical Association, 277, 1362–1368.CrossRefGoogle Scholar
  59. McGowan, P. O., Sasaki, A., D’Alessio, A. C., Dymov, S., Labonte, B., Szyf, M., et al. (2009). Epigenetic regulation of the glucorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience, 12(3), 241–243.CrossRefGoogle Scholar
  60. Meyer-Lindenberg, A., & Weinberger, D. R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews: Neuroscience, 7, 818–827.CrossRefPubMedGoogle Scholar
  61. Milner, B. (1959). The memory defect in bilateral hippocampal lesions. Psychiatric Research Reports: American Psychiatric Association, 11, 43–58.Google Scholar
  62. Mirescu, C., Peters, J. D., & Gould, E. (2004). Early life experience alters response of adult neurogenesis to stress. Nature Neuroscience, 7, 841–846.CrossRefPubMedGoogle Scholar
  63. Moran, M. (2008). Isnel: ‘Different kind of science’ poised to transform psychiatry. Psychiatric News, 43(13), 6.Google Scholar
  64. Murphy, G. M., Jr., Hollander, S. B., Rodrigues, H. E., Kremer, C., & Schatzberg, A. F. (2004). Effects of the serotonin transporter gene promoter polymorphism on mirtazapine and paroxetine efficacy and adverse events in geriatric major depression. Archives of General Psychiatry, 61(11), 1163–1169.CrossRefPubMedGoogle Scholar
  65. Nemeroff, C.B. (2008). Gene-environment interactions in the pathophysiology of depression: Implications for treatment selection. American College of Psychiatrist 2008 Annual Meeting and Pre-meetingGoogle Scholar
  66. Newcomer, J. W., Selke, G., Melson, A. K., Hershey, T., Craft, S., Richards, K., et al. (1999). Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Archives of General Psychiatry, 56, 527–533.CrossRefPubMedGoogle Scholar
  67. Nicholas, A., Munhoz, C. D., Ferguson, D., Campbell, L., & Sapolsky, R. (2006). Enhancing cognition after stress with gene therapy. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 26, 11637–11643.Google Scholar
  68. Oberlander, T. F., Weinber, J., Papsdorf, M., Grunau, R., Misri, S., & Devlin, A. M. (2008). Prenatal exposure to maternal depression, neonatal methylation of human glucorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics, 3(2), 97–106.CrossRefPubMedGoogle Scholar
  69. O'Connor, M. F., Wellisch, D. K., Stanton, A. L., Eisenberger, N. I., Irwin, M. R., & Lieberman, M. D. (2008). Craving love? Enduring grief activates brain's reward center. Neuroimage, 42, 969–972.CrossRefPubMedGoogle Scholar
  70. Ogawa, J. R., Sroufe, L. A., Weinfield, N. S., Carlson, E. A., & Egeland, B. (1997). Development and the fragmented self: longitudinal study of dissociative symptomatology in a nonclinical sample. Development and Psychopathology, 9, 855–879.CrossRefPubMedGoogle Scholar
  71. Pace, T. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., et al. (2006). Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. American Journal of Psychiatry, 163, 1630–1633.CrossRefPubMedGoogle Scholar
  72. Penfield, W., & Milner, B. (1958). Memory deficit produced by bilateral lesions in the hippocampal zone. AMA Archives of Neurology and Psychiatry, 79, 475–497.Google Scholar
  73. Pezawas, L., Verchinski, B. A., Mattay, V. S., Callicott, J. H., Kolachana, B. S., Straub, R. E., et al. (2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 24, 10099–10102.Google Scholar
  74. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience, 8, 828–834.CrossRefPubMedGoogle Scholar
  75. Pezawas, L., Meyer-Lindenberg, A., Goldman, A. L., Verchinski, B. A., Chen, G., Kolachana, B. S., et al. (2008). Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular Psychiatry, 13(7), 709–716.CrossRefPubMedGoogle Scholar
  76. Pitman, R. K., Sanders, K. M., Zusman, R. M., Healy, A. R., Cheema, F., Lasko, N. B., et al. (2002). Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry, 51, 189–192.CrossRefPubMedGoogle Scholar
  77. Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA, 301(23), 2462–2471.CrossRefPubMedGoogle Scholar
  78. Roiser JP, de Martino B, Tan GC, Kumaran D, Seymour B, Wood NW, Dolan RJ (2009). Journal of Neuroscience, 29(18), 5985–5991CrossRefGoogle Scholar
  79. Rosenblum, L. A., Coplan, J. D., Friedman, S., Bassoff, T., Gorman, J. M., & Andrews, M. W. (1994). Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates. Biological Psychiatry, 35, 221–227.CrossRefPubMedGoogle Scholar
  80. Sananbenesi, F., Fischer, A., Wang, X., Schrick, C., Neve, R., Radulovic, J., et al. (2007). A hippocampal Cdk5 pathway regulates extinction of contextual fear. Nature Neuroscience, 10, 1012–1019.CrossRefPubMedGoogle Scholar
  81. Sapolsky, R. M., Uno, H., Rebert, C. S., & Finch, C. E. (1990). Hippocampal damage associated with prolonged glucocorticoid exposure in primates. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 10, 2897–2902.Google Scholar
  82. Schuengel, C., Bakermans–Kranenburg, M. J., & Van Ijzendoorn, M. H. (1999). Frightening maternal behavior linking unresolved loss and disorganized infant attachment. Journal of Consulting and Clinical Psychology, 67, 54–63.CrossRefPubMedGoogle Scholar
  83. Schulte-Rüther, M., Markowitsch, H. J., Fink, G. R., & Piefke, M. (2007). Mirror neuron and theory of mind mechanisms involved in face-to-face interactions: A functional magnetic resonance imaging approach to empathy. Journal of Cognitive Neuroscience, 19, 1354–1372.CrossRefPubMedGoogle Scholar
  84. Schwartz, C. E., Wright, C. I., Shin, L. M., Kagan, J., & Rauch, S. L. (2003). Inhibited and uninhibited infants “grown up”: Adult amygdalar response to novelty. Science, 300, 1952–1953.CrossRefPubMedGoogle Scholar
  85. Shaw, D. S., Owens, E. B., Vondra, J. I., Keenan, K., & Winslow, E. B. (1996). Early risk factors and pathways in the development of early disruptive behavior problems. Development and Psychopathology, 8, 679–699.CrossRefGoogle Scholar
  86. Shin, L. M., Rauch, S. L., & Pitman, R. K. (2006). Amygdala, medial prefrontal cortex, and hippocampal function in PTSD. Annals of the New York Academy of Sciences, 1071, 67–69.CrossRefPubMedGoogle Scholar
  87. Squire, L. R., & Zola-Morgan, M. (1991). The medial temporal lobe memory system. Science, 253, 1380–1386.CrossRefPubMedGoogle Scholar
  88. Sroufe, L. A. (2005). Attachment and development: A prospective, longitudinal study from birth to adulthood. Attachment & Human Development, 7, 349–367.CrossRefGoogle Scholar
  89. Suomi, S. J. (1999). Attachment in rhesus monkeys. In J. Cassdy & P. R. Shaver (Eds.), Handbook of attachment: theory, research and clinical applications (pp. 181–197). New York: Guilford.Google Scholar
  90. Suomi, S. J. (2003). Gene-environment interactions and the neurobiology of social conflict. Annuals of the New York Academy of Sciences, 1008, 132–139.CrossRefGoogle Scholar
  91. Thomas, C., Hyppönen, E., & Power, C. (2008). Obesity and type 2 diabetes risk in midadult life: the role of childhood adversity. Pediatrics, 121, 1240–1249.CrossRefGoogle Scholar
  92. van den Bos, R., Homberg, J., Gijsbers, E., den Heijer, E., & Cuppen, E. (2009). The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology, 56(2), 493–498.CrossRefPubMedGoogle Scholar
  93. Weaver, I. C., Cervoni, N., Champagne, F. A., D’Alessio, A. C., Sharma, S., Seckl, J. R., et al. (2004). Epigenetic programming by maternal behavior. Nature Neuroscience, 7, 847–854.CrossRefPubMedGoogle Scholar
  94. Weinberger, D.R. (2009, July 17). How do genes cause mental illness? The good, the bad, and the ugly. Second Annual Chairs in Psychiatry Summit, Charleston, SCGoogle Scholar

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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jerald Kay
    • 1
  1. 1.Boonshoft School of Medicine, Wright State UniversityDaytonUSA

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