Imaging-Based Assessment and Modeling of the Structures of the Myocardium

  • Edward W. Hsu
  • Lindsey J. Healy
  • Daniel R. Einstein
  • Andrew P. Kuprat


A precise knowledge of the microstructures of the myocardium such as myocyte organization and myofiber orientation is necessary to better understand material and functional properties of the tissue. By characterizing the diffusion of water exerted by its molecular environment, magnetic resonance diffusion tensor imaging has emerged as a viable alternative to conventional histology for mapping tissue fibers and offers advantages of being nondestructive, relatively convenient, and inherently 3D. This chapter presents assessments and modeling of myocardial structures via diffusion tensor imaging, including their principles, validation, applications, and potential directions for future development.


Fractional Anisotropy Diffusion Tensor Anisotropic Diffusion Beating Heart Magnetic Resonance Imaging Signal 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Edward W. Hsu
    • 1
  • Lindsey J. Healy
    • 1
  • Daniel R. Einstein
    • 2
  • Andrew P. Kuprat
    • 2
  1. 1.Department of BioengineeringUniversity of UtahSalt Lake CityUSA
  2. 2.Pacific Northwest National LaboratoryRichlandUSA

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