Myc and Control of Tumor Neovascularization

  • Prema Sundaram
  • Chi V. Dang
  • Andrei Thomas-Tikhonenko
Part of the Cancer Genetics book series (CANGENETICS)


The hallmark of Burkitt’s and some other non-Hodgkin lymphomas and leukemias is the (8;14) translocation that subjects the c-myc proto-oncogene to the control of a heavy chain gene enhancer (Dalla-Favera et al. 1982; Taub et al. 1982). Additionally, double minute chromosomes (dmin) containing amplified copies of the c-Myc gene are commonly detected in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) (Storlazzi et al. 2004). In parallel, rearrangements and amplifications of the c-MYC locus are hallmarks of many solid neoplasms. For example, the LINE-1 element insertion leads to MYC rearrangement in the case of breast carcinoma (Morse et al. 1988) and up to 50% of breast carcinomas show a gain in copy number of the 8q24 band containing MYC (Ioannidis et al. 2003). Another Myc family member, MYCN, is amplified in neuroblastoma cell lines (Kohl et al. 1983) and primary tumors, where it correlates with advance disease stage (Brodeur et al. 1984). Yet, despite the wealth of data implicating Myc in the pathogenesis of cancer, its exact contribution to neoplastic traits is not completely understood. Much recent evidence points towards the involvement of Myc in cell-extrinsic processes, such as angiogenesis.


Acute Myeloid Leukemia Connective Tissue Growth Factor VEGF Expression Tumor Neovascularization VEGF mRNA 



The authors wish to thank the members of their laboratories, in particular Dr Michael Dews, and also Dr. Celeste Simon (Penn), for many stimulating discussions concerning the nature of Myc-driven angiogenesis.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Prema Sundaram
    • 1
  • Chi V. Dang
    • 2
  • Andrei Thomas-Tikhonenko
    • 3
  1. 1.Department of Pathology and Laboratory MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.University of Pennsylvania and the Children’s Hospital of Philadelphia, 516H Abramson Research CenterPhiladelphiaUSA

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