Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment

  • Donita C. Brady
  • Jamie K. Alan
  • Adrienne D. Cox
Part of the Cancer Genetics book series (CANGENETICS)


Unlike Ras proteins that are oncogenically mutated in 30% of human cancers, known naturally occurring mutations in Rho GTPases are limited to RhoH (a.k.a. ARHH). This gene has been found to be rearranged in non-Hodgkin’s lymphomas and multiple myeloma, along with mutations in the 5UTR in diffuse large cell lymphomas (Preudhomme et al. 2000; Pasqualucci et al. 2001). The common rearrangement found in these hematopoietic cancers is caused by a t(3;4)(q27; p11–13) chromosomal translocation resulting in a gene fusion with the BCL3/LAZ3 oncogene (Dallery-Prudhomme et al. 1997). How these RhoH translocations and hypermutations – as well as other aberrantly expressed Rho GTPases – contribute to the cancer pathogenesis remains an open question. However, a large body of evidence points to their involvement in EMT.


Actin Polymerization Small GTPases Adherens Junction Squamous Cell Carcinoma Cell Cdc42 Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Donita C. Brady
    • 1
  • Jamie K. Alan
    • 1
  • Adrienne D. Cox
    • 2
  1. 1.Department of PharmacologyUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Departments of Radiation Oncology and Pharmacology,Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillUSA

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