In situ Breast Cancer

  • Brian L. Sprague
  • Amy Trentham-Dietz


Breast carcinoma in situ (BCIS) is the penultimate step in the progression of normal epithelium from hyperplasia to invasive breast cancer. There are two types of BCIS: ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Most BCIS of both types originate in the terminal duct lobular unit, with the type of cells and their growth pattern providing the distinguishing features. DCIS is a proliferation of presumably malignant epithelial cells confined to the mammary ducts and lobules without demonstrable evidence of invasion through the basement membrane into the surrounding stroma (Harris et al. 1997). DCIS is typically detected by mammography, as it is frequently associated with microcalcifications (Damiani et al. 2002). LCIS is a solid proliferation of generally small and often loosely cohesive cells with small, uniform, round to oval nuclei (Harris et al. 1997). The overall lobular architecture is maintained and the cells are contained within the basement membrane. LCIS is often multicentric and bilateral and is most commonly diagnosed incidentally by a breast procedure performed for another reason (Damiani et al. 2002).


Breast Cancer Breast Cancer Risk Invasive Breast Cancer Benign Breast Disease Postmenopausal Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Population Health SciencesUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.University of Wisconsin Paul P. Carbone Comprehensive Cancer CenterMadisonUSA

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