Common Genetic Susceptibility Loci
Common genetic variants, that is, variants withResmailearch greater than 5% frequency in the population, are likely to contribute greatly to inherited genetic susceptibility to breast cancer. As with many other common diseases, the success of recent genome-wide association scans has revived research into genetic susceptibility to breast cancer and ended a decade of largely unsuccessful candidate-gene association studies.
KeywordsBreast Cancer Susceptibility Locus Common Genetic Variant Breast Cancer Association Consortium Common Susceptibility
- Fisher R (1918) The correlation between relatives on the supposition of Mendelian inheritance. Royal Society of Edinburgh, EdinburghGoogle Scholar
- Lange K (2002) Mathematical and statistical methods for genetic analysis. Springer, New YorkGoogle Scholar
- Oestergaard MZ, Kalmyrzaev B, Tyrer J, Morrison J, Easton D et al (2008a) Genome-wide genetic interaction scan for breast cancer susceptibility negative. submittedGoogle Scholar
- Oestergaard MZ, Tian W, Tasan M, Derti A, Kalmyrzaev B et al (2008b) Using functional linkage to map genetic interactions for breast cancer susceptibility. submittedGoogle Scholar