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Perspectives On DNA Looping

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Mathematics of DNA Structure, Function and Interactions

Part of the book series: The IMA Volumes in Mathematics and its Applications ((IMA,volume 150))

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Abstract

DNA looping is a ubiquitous regulatorymechanism which can be involved in DNA transcription, ecombination, repair, etc. Here, I will focus on protein-mediated DNA looping as a mechanism of tran-scriptional regulation. Indeed, such topological change in DNA is known to repress and/or activate many prokaryotic and viral genes [1–4] and is believed to mediate interaction between promoters and enhancers as well as insulate them in eukaryotes [5–9].

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Authors and Affiliations

  1. Department of Physics, Emory University, 30322-2430, Atlanta, GA, USA

    Laura Finzi

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  1. Laura Finzi
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Correspondence to Laura Finzi .

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Editors and Affiliations

  1. Dept. Pharmacology & Genome Center, University of California, Davis, E. Health Sciences Drive 451, Davis, 95616, USA

    Craig John Benham

  2. Dept. Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, 30332-0400, USA

    Stephen Harvey

  3. Dept. Chemistry & Chemical Biology, Rutgers State University of New Jersey, Taylor Rd. 610, Piscataway, 08854-8087, USA

    Wilma K. Olson

  4. Dept. Mathematics, Florida State University, Tallahassee, 32306-4510, USA

    De Witt Sumners

  5. Dept. Mathematics, University of Pittsburgh, Thackeray Hall 301, Pittsburgh, 15260, USA

    David Swigon

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Finzi, L. (2009). Perspectives On DNA Looping. In: Benham, C., Harvey, S., Olson, W., Sumners, D., Swigon, D. (eds) Mathematics of DNA Structure, Function and Interactions. The IMA Volumes in Mathematics and its Applications, vol 150. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0670-0_4

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