Chromosomal Position Effect and Aging

  • Eric Gilson
  • Frédérique Magdinier


Aging is a complex biological process that manifests through cellular, physical, and metabolic changes in all types of tissues. Changes in chromosome structure and function throughout life play a pivotal role in this irreversible physiological process by affecting gene expression, replication, recombination, DNA repair, and epigenetic programming. Upon exogenous stress or simply as the result of cellular metabolism and cellular division, DNA rearrangements or redistribution of epigenetic factors might alter the chromatin environment and expression of genes regulating the aging process by the so-called chromosomal position effect. These changes can vary from cell to cell and can be associated with variegated pattern of gene expression. We will discuss here what is known on the mechanisms of various types of chromosomal position effects and their consequences on the aging process.


Chromosomal position effect Telomeric position effect Epigenetics Aging Telomeres Chromatin 


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, UCBL1, IFR128. 46 allée d’ItalieLyon Cedex 07France

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