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Epigenetic Drift and Aging

  • Ester Lara*
  • Vincenzo Calvanese*
  • Mario F. Fraga

Abstract

Epigenetics of aging is an emerging field that promises exciting revelations in the near future. Epigenetic pathways, including DNA methylation and histone modification, are determinants of normal development and can change during aging. Some of the epigenetic alterations described during aging, as hypermethylation at specific promoters and decrease of global DNA methylation, are also associated with tumour development. The epigenetic changes occurring during development and aging can be stochastic or depend on environmental factors. Future challenges in the field involve the determination of the precise molecular mechanisms that create age-dependent epigenetic variation and how these epigenetic changes affect the aging phenotype.

Keywords

methylation histone modifications aging development 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ester Lara*
    • 1
  • Vincenzo Calvanese*
    • 1
  • Mario F. Fraga
    • 1
    • 2
  1. 1.Department of Immunology and OncologyNational Center for Biotechnology, CNB-CSICCantoblancoSpain
  2. 2.Laboratorio de Epigenética del Cáncer, Instituto Universitario de Oncología del Principado de Asturias (IUOPA)Universidad de OviedoOviedoSpain

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