The IMGT/HLA Database
It is almost 10 years since the IMGT/HLA Database was released providing the HLA community with a searchable repository of highly curated sequences. The HLA complex is located within the 6p21.3 region on the short arm of human chromosome 6 and contains more than 220 genes of diverse function. Many of the genes encode proteins of the immune system and are highly polymorphic. The naming of these HLA genes and allele sequences and their quality control is the responsibility of the WHO Nomenclature Committee for Factors of the HLA System. The IMGT/HLA Database acts as the repository for these sequences, and is recognised as the primary source of up-to-date and accurate HLA sequences. The IMGT/HLA Database website provides a number of tools for accessing the database; these include allele reports, sequence alignments and sequence similarity searches. Regular updates to the website ensure that the all the new and confirmatory sequences submitted to the WHO Nomenclature Committee are dispersed to the wider HLA community.
KeywordsAlignment Tool Nomenclature Committee European Bioinformatics Institute European Molecular Biology Laboratory Flat File
We would like to thanks Matthew Waller and Sylvie Fail for their work on development and curation of the database. We would like to acknowledge the support of the following organisations: Histogenetics, Abbott Laboratories Inc., the American Society for Histocompatibility and Immunogenetics , the Anthony Nolan Bone Marrow Trust, Biotest, BAG Healthcare, Dynal, the European Federation for Immunogenetics, Qiagen, One Lambda Inc, Invitrogen, Innogenetics, the National Marrow Donor Program, the Marrow Foundation and Tepnel Lifecodes. Initial support for the IMGT/HLA database project was from the Imperial Cancer Research Fund (now Cancer Research UK) and an EU Biotech grant (BIO4CT960037).
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