In this chapter we shall review recent developments in computational vaccinology, highlighting work in the area of epitope and antigen identification, and the discovery of delivery vectors and adjuvants. These diverse activities all have the potential to reduce significantly the laboratory resource needed for efficient vaccine discovery. We discuss how computational analysis of pathogenic genomes by epitope mapping and reverse vaccinology can provide viable vaccine targets.
KeywordsMajor Histocompatibility Complex Visceral Leishmaniasis Cell Epitope Major Histocompatibility Complex Molecule CCR4 Antagonist
- Bulashevska A, Eils R (2006) Predicting protein subcellular locations using hierarchical ensemble of Bayesian classifiers based on Markov chains. BMC Bioinformatics. 7:298Google Scholar
- Merino EF, Fernandez-Becerra C, Durham AM, Ferreira JE, Tumilasci VF, d’Arc-Neves J, da Silva-Nunes M, Ferreira MU, Wickramarachchi T, Udagama-Randeniya P, Handunnetti SM, Del Portillo HA (2006) Multi-character population study of the vir subtelomeric multigene superfamily of Plasmodium vivax, a major human malaria parasite. Mol Biochem Parasitol 149(1):10–16CrossRefPubMedGoogle Scholar
- Palma-Carlos AG, Santos AS, Branco-Ferreira M, Pregal AL, Palma-Carlos ML, Bruno ME, Falagiani P, Riva G (2006) Clinical efficacy and safety of preseasonal sublingual immunotherapy with grass pollen carbamylated allergoid in rhinitic patients. A double-blind, placebo-controlled study. Allergol Immunopathol (Madr) 34(5):194–198CrossRefGoogle Scholar
- Vivona S, Bernante F, Filippini F.(2006) NERVE: new enhanced reverse vaccinology environment. BMC Biotechnol 6:35Google Scholar