Nanodiamonds pp 175-188 | Cite as

Polymeric Encapsulation of Nanodiamond–Chemotherapeutic Complexes for Localized Cancer Treatment

  • Robert Lam
  • Mark Chen
  • Houjin Huang
  • Eiji Ōsawa
  • Dean Ho


A diverse range of synthetic and natural nanoscale carriers in both particle and film/scaffold formats have been developed to enable controlled therapeutic release. Examples of these systems include metallic nanoparticles, polymer–protein conjugates, liposomes, micelles, dendrimers, polyelectrolyte films, copolypeptides, carbon nanotubes, etc. Nanodiamonds (NDs), in particular, possess several advantageous properties that make them suitable for advanced drug delivery while also remaining biocompatible. We have previously developed a method of functionalizing aqueous solubilized NDs of diameter 2–8 nm with doxorubicin (DOX), a clinically relevant chemotherapeutic capable of inducing potent DNA fragmentation and cellular apoptosis. This work has realized a scalable approach toward the fabrication of ND-embedded polymer microfilms for localized and sustained drug elution for post-operative chemotherapy. Due to their high surface-area-to-volume ratio and noninvasive dimensions, NDs are capable of extremely high loading capacities of therapeutic compounds. In addition, we have demonstrated the capability of ND binding with a broad range of charged therapeutic molecules via physical interactions due to their inherent surface charge properties. NDs are also biologically stable and appear to be non-toxic, which prevents adverse stressful/inflammation-inducing cellular reactions in the event that they are dispersed throughout the body for either systemic or more localized release activity. The combination of these properties in one system makes the NDs promising platforms for slow-release therapeutics to treat a broad array of physiological disorders (e.g. cancer, heart disease, wound healing, etc.).


Drug Release Hybrid Film Burst Release Oxygen Plasma Treatment Drug Delivery Strategy 
These keywords were added by machine and not by the authors.


The authors gratefully acknowledge support from the National Science Foundation, a V Foundation for Cancer Research V Scholars Award and National Institutes of Health grant U54 A1065359


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Robert Lam
    • 1
  • Mark Chen
    • 1
  • Houjin Huang
    • 1
  • Eiji Ōsawa
    • 2
  • Dean Ho
    • 1
    • 3
  1. 1.Departments of Biomedical and Mechanical EngineeringRobert R. McCormick School of Engineering and Applied Science, Northwestern UniversityEvanstonUSA
  2. 2.Nanocarbon Research Institute, Ltd., Asama Research Extension Center, Shinshu UniversityUedaJapan
  3. 3.Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Galter PavilionChicagoUSA

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