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The Local Cardiac Renin-Angiotensin Aldosterone System pp 51–66Cite as

Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage

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Abstract

Transgenic animal models are important tools, which have been extensively used to gain insight into the molecular mechanisms of human diseases. We have created two transgenic consomic rat strains, in which malignant hypertension can be induced by administration of a nontoxic xenobiotic. Studies combining quantitative trait locus (QTL) analysis, pathological examination and molecular biological investigation have demonstrated that the renal renin–angiotensin system (RAS), especially angiotensin converting enzyme (Ace), is a key factor affecting the degree of hypertensive kidney damage in these strains.

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Acknowledgments

This work was supported by the Wellcome Trust CVRI and Functional Genomics initiatives. JM is a recipient of the Wellcome Trust Principle Fellowship.

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Authors and Affiliations

  1. Molecular Physiology Laboratory, Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, EH16 9AG, Edinburgh, Scotland, UK

    Xiaoujun Liu, Christopher O.C. Bellamy, Linda J. Mullins, Donald Dunbar & John J. Mullins

Authors
  1. Xiaoujun Liu
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  2. Christopher O.C. Bellamy
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  3. Linda J. Mullins
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  4. Donald Dunbar
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  5. John J. Mullins
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Editors and Affiliations

  1. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Edward D. Frohlich

  2. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Richard N. Re

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Liu, X., Bellamy, C.O., Mullins, L.J., Dunbar, D., Mullins, J.J. (2009). Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage. In: Frohlich, E., Re, R. (eds) The Local Cardiac Renin-Angiotensin Aldosterone System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0528-4_6

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  • DOI: https://doi.org/10.1007/978-1-4419-0528-4_6

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0527-7

  • Online ISBN: 978-1-4419-0528-4

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