Pathophysiologic Implications of Cell Swelling in the Failing Heart: Influence of Intracrine and Extracellular Renin–Angiotensin Systems
The regulation of cell volume is of fundamental importance to heart cell function and is involved on genetic expression, growth and activation of ionic channels including the swelling-activate chloride channel which reduces the action potential duration and facilitates the generation of cardiac arrhythmias. Extracellular renin or angiotensin II cause heart cell swelling through inhibition of the sodium pump and activation of the Na-K-2 Cl cotransporter while intracellular Ang II reduces cell volume through an activation of the electrogenic sodium pump. Ang (1-7) also reduces cell volume by activation of the sodium pump. The implications of these findings to cardiac arrhythmia during ischemia reperfusion are discussed.
KeywordsAction Potential Duration Angiotensin System Heart Cell Sodium Pump Cell Volume Regulation
This work was supported in part by grant GM-61838 from NIH.
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