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Intracellular Accumulation and Nuclear Trafficking of Angiotensin II and the Angiotensin II Type 1 Receptor

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The Local Cardiac Renin-Angiotensin Aldosterone System

Abstract

Despite the fact that the concept of an intracellular or intracrine renin-angiotensin system has gained general acceptance over the last decade, several questions continue to trouble this research area. Empirical evidence supports the existence of intracellular angiotensin II peptide and nuclear angiotensin II type 1 receptor, translocation of the plasma membrane receptor to the nucleus, and functionality of the intracellular RAS components. However, the mechanism by which intracellular angiotensin II is generated or alternatively internalized and reutilized, and the means by which the AT1 receptor is transported to the nuclear membrane remain unclear. This paper reviews some of the relevant literature and ideas related to intracellular trafficking of angiotensin II and its cognate receptors and presents new supporting data for alternative mechanisms by which the receptors and angiotensin II might accumulate in the nuclear compartment.

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Author information

Authors and Affiliations

  1. Molecular Genetics, Ochsner Clinic Foundation, 70121, New Orleans, LA, USA

    Julia L. Cook

  2. Ochsner Clinic Foundation, 70121, New Orleans, LA, USA

    Richard N. Re MD (Scientific Director)

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  1. Julia L. Cook
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  2. Richard N. Re MD
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Correspondence to Julia L. Cook .

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Editors and Affiliations

  1. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Edward D. Frohlich

  2. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Richard N. Re

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Cook, J.L., Re, R.N. (2009). Intracellular Accumulation and Nuclear Trafficking of Angiotensin II and the Angiotensin II Type 1 Receptor. In: Frohlich, E., Re, R. (eds) The Local Cardiac Renin-Angiotensin Aldosterone System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0528-4_4

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  • DOI: https://doi.org/10.1007/978-1-4419-0528-4_4

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-0527-7

  • Online ISBN: 978-1-4419-0528-4

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