Renin, Prorenin, and the (Pro)renin Receptor

  • Genevieve Nguyen
  • Aurelie Contrepas
Conference paper


The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin-angiotensin system (RAS) and has brought prorenin back in the spotlight. The receptor known as (P)RR for (pro)renin receptor binds both renin and prorenin, and binding triggers intracellular signaling involving the MAP kinases ERK1/2 and p38. The MAP kinases activation in turn upregulates the expression of profibrotic genes, potentially leading to fibrosis, growth, and remodeling. Simultaneously, binding of renin to (P)RR increases its angiotensin I generating activity, whereas binding of prorenin induces the inactive prorenin to become enzymatically active. These biochemical characteristics of (pro)renin binding to (P)RR allow to distinguish two aspects for the new (pro)renin/(P)RR system, an angiotensin-independent function related to the intracellular signaling and its downstream effects, and an angiotensin-dependent aspect related to the increased generation of angiotensin I on the cell surface. Ongoing experimental studies should now determine which of the two aspects is the most important in pathological situations.


Renin Receptor Aortic Vascular Smooth Muscle Cell Plasma Prorenin Prorenin Level Handle Region Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



designate renin and prorenin



Ang I and Ang II:

angiotensin I and angiotensin II


angiotensin converting enzyme


handle region peptide


(pro)renin receptor blocker


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Genevieve Nguyen
    • 1
  • Aurelie Contrepas
    • 2
  1. 1.(INSERM) Unit 833 and Collège de France, Experimental Medecine UnitInstitut de la Santé et de la Recherche MédicaleParisFrance
  2. 2.INSERM U36, College de FranceParisFrance

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