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Salt and Heart: RAAS Involvement

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The Local Cardiac Renin-Angiotensin Aldosterone System

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Abstract

The role of high dietary salt intake was previously thought to be restricted only to the effects on arterial pressure. However, a large body of evidence has accumulated over the last two decades pointing to the potent adverse effects of salt excess on cardiac structure and function. The role of the renin–angiotensin–aldosterone system as a key player in mediating these effects has been increasingly appreciated in recent years. Moreover, identification of angiotensin-(1-7), its receptor mas, and enzymes involved in its metabolism challenges our concept that only increased angiotensin II activity is responsible for cardiac injury in salt-sensitive hypertension.

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Acknowledgments

This work was supported by awards from the National Institutes of Health (HL-51952 to CMF), American Heart Association, Mid-Atlantic Affiliate (0765308U to JV), and WFUSM Venture Fund (to JV). Additionally, the authors gratefully acknowledge grant support in part provided by Unifi, Inc., Greensboro, NC, and Farley-Hudson Foundation, Jacksonville, NC.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Hypertension & Vascular Research Center, Wake Forest University School of Medicine, 27157, Winston-Salem, NC, USA

    Jasmina Varagic & Carlos M. Ferrario

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  1. Jasmina Varagic
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  2. Carlos M. Ferrario
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Correspondence to Jasmina Varagic .

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  1. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Edward D. Frohlich

  2. Ochsner Clinic Foundation, Jefferson Highway 1514 , New Orleans, 70121, U.S.A.

    Richard N. Re

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Varagic, J., Ferrario, C.M. (2009). Salt and Heart: RAAS Involvement. In: Frohlich, E., Re, R. (eds) The Local Cardiac Renin-Angiotensin Aldosterone System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0528-4_16

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  • DOI: https://doi.org/10.1007/978-1-4419-0528-4_16

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