Abstract
In the past decade observations have been made showing that cardiomyocyte apoptosis is an integral feature of the structural remodeling of the hypertensive hypertrophied left ventricle. The loss and functional abnormalities of apoptotic cardiomyocytes may be a contributing cause to the transition from left ventricular hypertrophy to heart failure in hypertension. Although the available evidence suggests that apoptosis can be induced in cardiomyocytes by a variety of factors and pathways, a number of findings suggest that the effectors of the renin–angiotensin–aldosterone system can be critically involved in cardiomyocyte apoptosis in hypertension. This review will summarize recent evidence demonstrating the potential contribution of angiotensin II and other components of the system to cardiomyocyte apoptosis in hypertensive heart disease. In addition, some evidence regarding strategies aimed to detect and prevent apoptosis of cardiomyocytes in hypertensive patients will be considered.
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Acknowledgments
This work was funded through the agreement between the Foundation for Applied Medical Research (FIMA) and UTE project CIMA, the Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (RECAVA) from the Instituto de Salud Carlos III, Ministry of Health, Spain (grant RD06/0014/0008), and the European Union (InGenious HyperCare, grant LSHM-CT-2006-037093).
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González, A., Ravassa, S., López, B., Beaumonta, J., Díez, J. (2009). Renin–Angiotensin–Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease. In: Frohlich, E., Re, R. (eds) The Local Cardiac Renin-Angiotensin Aldosterone System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0528-4_14
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DOI: https://doi.org/10.1007/978-1-4419-0528-4_14
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