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Collecting Duct Renin: A Critical Linkin Angiotensin II-Dependent Hypertension

  • Minolfa C. Prieto
  • L. Gabriel Navar
Conference paper

Abstract

All of the components needed for angiotensin II generation are present within the renal tubular network of the kidney. This brief review is focused on recent evidence demonstrating that inappropriate activation of renin in distal nephron segments by acting on angiotensinogen generated in the proximal tubule cells and delivered to the distal nephron may contribute to increased distal intrarenal angiotensin II formation, sodium retention, and development and progression of hypertension. Moreover, mechanisms regulating collecting duct renin during Ang II-dependent hypertension are discussed.

Keywords

Angiotensin Converting Enzyme Principal Cell Distal Nephron Collect Duct Cell Angiotensin Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Research performed by the authors has been supported by grants from National Heart, Lung, and Blood Institute Grant HL-26731, National Institutes of Health Grant P20-RR-017659 from the Institutional Developmental Award (IdeA) program of NCRR, Eunice Kennedy Shriver National Institute of Child Health & Human Development Grant K12HD043451, and the Louisiana Board of Regents Millennium Health Excellence Fund (2001-06-07).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Minolfa C. Prieto
    • 1
  • L. Gabriel Navar
    • 1
  1. 1.Department of PhysiologyTulane University Health Sciences CenterNew OrleansUSA

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