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Renin Cell Identity and Homeostasis

  • R. Ariel Gómez
  • Maria Luisa S. Sequeira Lopez
  • Xuan Jin
  • Magali Cordaillat
  • Ellen Steward Pentz
Conference paper

Abstract

Renin-expressing cells are precursors for vascular smooth muscle cells within the kidney, which in turn are capable of dedifferentiating and synthesize renin in response to challenges to homeostasis. The mechanisms that determine the identity of renin cells are the subject of many studies. Using a cell model of renal arteriolar smooth muscle cells dually labeled with fluorescent markers we showed that in vitro the cells can reexpress renin upon cAMP stimulation. In addition, reexpression of renin through the cAMP pathway involves chromatin remodeling by acetylation of histone 4. Further experiments confirmed that histone acetyl transferases play an essential role in the maintenance of the renin cell identity.

Keywords

Yellow Fluorescent Protein Cyan Fluorescent Protein cAMP Pathway cAMP Responsive Element Histone Acetyl Transferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • R. Ariel Gómez
    • 2
  • Maria Luisa S. Sequeira Lopez
    • 1
  • Xuan Jin
    • 1
  • Magali Cordaillat
    • 1
  • Ellen Steward Pentz
    • 1
  1. 1.Department of PediatricsUniversity of Virginia School of MedicineCharlottesvilleUSA
  2. 2.Department of Pediatrics & BiologyUniversity of Virginia School of MedicineCharlottesvilleUSA

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