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Classification of Anticancer Drugs Based on Therapeutic Targets

  • Enrique Espinosa
  • César Gómez Raposo
Chapter
Part of the Macromolecular Anticancer Therapeutics book series (CDD&D)

Abstract

The arrival of a great number of new antineoplastic agents has made it necessary to reclassify all of them. Virtually any mechanism that can provide tumour cells with proliferative advantages over normal cells is being investigated in the search for active drugs. Growth factors and their receptors, intracellular metabolic pathways, pro-angiogenic molecules and many more have become potential targets.

We herein propose a classification of anticancer drugs based on the target. Drug may act at different levels: cancer cells, endothelium, extracellular matrix, the immune system and host cells. The tumour cell can be targeted at the DNA, RNA or protein level. Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small targeted molecules are directed against proteins. The endothelium and extracellular matrix may also be affected by specific antibodies and small molecules.

Keywords

Vascular Endothelial Growth Factor Renal Cell Carcinoma Medullary Thyroid Carcinoma Main Side Effect Cancer Immunotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

bFGF

basic fibroblast growth factor

CDK-2

cyclin-dependent kinase 2

cDNA

complementary DNA

CEA

carcinoembryonic antigen

CTLA-4

cytotoxic T-lymphocyte-associated antigen-4

DNA

deoxyribonucleic acid

EGFR

epidermal growth factor receptor

ERCC1

excision repair-defective complementation group 1

FGFR

fibroblast growth factor receptor

GM-CSF

granulocyte macrophage colony stimulating factor

HER

human epidermal growth factor receptor

HIF-1

hypoxia inducible factor-1

HMG1

high motility group 1

HMG2

high motility group 2

HPMA

N-(2-hydroxypropyl)methacrylamide

IKK inhibitors

I-kappaB kinase inhibitors

IL-8

interleukin-8

LH-RH

leutinizing hormone releasing hormone

MMPs

matrix metalloproteinases

mRNA

messenger RNA

NF-kB

nuclear factor–kappaB

NSCLC

non-small cell lung cancer

PDEGF

platelet-derived endothelial growth factor

PKC

protein kinase C

RNA

ribonucleic acid

RNAi

RNA interference

SOD

superoxide dismutase

STATs

signal transducers and activators of transcription

TGF

transforming growth factor

VEGF

vascular endothelial growth factor

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Servicio de Oncología MédicaHospital La Paz, P° de la CastellanaMadridSpain
  2. 2.Service of OncologyHospital Infanta Sofía, San Sebastián de los ReyesMadridSpain

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