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Other Hereditary Breast Cancer Syndromes and Genes

  • Katherine L. Nathanson
Chapter
Part of the Cancer Genetics book series (CANGENETICS)

Abstract

The major genes associated with inherited susceptibility to breast cancer are BRCA1 and BRCA2. However, breast cancer is a component of other cancer susceptibility syndromes, including Li-Fraumeni syndrome, Cowden syndrome, Peutz-Jeghers syndrome and Hereditary Gastric Cancer. This chapter is divided into two major parts: (1) rare familial cancer syndromes with breast cancer as a component (Table 7.1) and (2) mutations in DNA damage response genes associated with an increased risk of breast cancer, notably in families with multiple breast cancer cases.

Keywords

Breast Cancer Breast Cancer Risk Fanconi Anemia Breast Cancer Susceptibility Familial Breast Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Medicine, Division of Medical GeneticsSchool of Medicine, University of PennsylvaniaPhiladelphiaUSA

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