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Recent Advances in Understanding the Cellular Functions of BRCA1

  • Ellen Solomon
  • Joanna R. Morris
Chapter
Part of the Cancer Genetics book series (CANGENETICS)

The first breast and ovarian cancer predisposition gene, BRCA1, was cloned over 14 years ago. The features of BRCA1-defective cells and tumours have been well described; these display genomic instability and multiple centrosomes, are sensitive to DNA-damaging agents that rely on homologous recombination (HR) for repair and the tumours are of a particular pathological subtype (known as basal). Yet the precise molecular defect downstream of BRCA1 loss-of-function remains elusive. More than 70 BRCA1-interacting proteins have been described and in this review we will attempt to draw together recent findings about BRCA1 complexes and activity that inform our current understanding of the cellular tumour suppressor function of BRCA1.

Keywords

Ring Domain BRCA1 Carrier Centrosome Amplification RAD51 Focus Ubiquitin Conjugate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ellen Solomon
    • 1
  • Joanna R. Morris
    • 1
  1. 1.Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, and Breakthrough Breast Cancer Research UnitKing’s College Medical School, Guy’s HospitalLondonUK

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