Glioblastoma pp 365-397 | Cite as

Immunotherapy for Glioblastoma

  • Azizul Haque
  • Mitzi Nagarkatti
  • Prakash Nagarkatti
  • Naren L. Banik
  • Swapan K. Ray
Chapter

Abstract

The most common and deadliest brain tumor is glioblastoma, which escapes immune recognition and kills the patients with a year of diagnosis. Glioblastomas, like other malignancies, are highly capable of overcoming host immune defenses through a variety of mechanisms some of which are quite clear. Currently, there is a growing interest in developing immunotherapeutics for treatment of glioblastomas; however, very little is known about glioblastoma-specific immune responses. A better understanding of the molecular interactions between the tumor and the host immune system may allow the development of novel integrated approaches based on the simultaneous control of tumor escape pathways and the activation of anti-tumor immune responses. An appropriate combination therapy that may induce long-lasting immune responses against glioblastoma should be attempted. The primary goal of immunotherapy for glioblastoma should be to overcome tolerance and to re-educate the immune system, when the tumor burden is reduced following surgery, radiotherapy and chemotherapy. This article describes the latest developments in the glioblastoma immunology and immunotherapy.

Keywords

Glioblastoma Combination therapy Immune responses Immunotherapy 

Notes

Acknowledgments

This work was supported in part by the grants to A.H. from the Leukemia and Lymphoma Society (#3024) and MUSC Hollings Cancer Center, also by the P01 grant (AT-3961 to M.N. and P.N.), and by the R01 grants (AI-53703, AI-58300, and HL-58641 to M.N.; ES-9098 and DA-16545 to P.N.; NS-41088 and NS-45967 to N.L.B.; and CA-91460 and NS-57811 to S.K.R.) from the National Institutes of Health (Bethesda, MD, USA).

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Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  • Azizul Haque
  • Mitzi Nagarkatti
  • Prakash Nagarkatti
  • Naren L. Banik
  • Swapan K. Ray
    • 1
  1. 1.Department of Pathology, Microbiology, and ImmunologyUniversity of South Carolina School of MedicineColumbiaUSA

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