Finding Repeating Synaptic Inputs in a Single Neocortical Neuron
A goal in neuroscience is to understand what occurs when large numbers of interconnected neurons actively communicate with each other to create perception. An important part in this goal is to observe large numbers of neurons engaged in such communication. Outlined here is an approach to this challenge. This approach uses a single neuron as a “microphone” of cortical activity. As potentially thousands of neurons may connect with a single neuron in the mammalian sensory neocortex, then it may be possible to record large networks by recording the synaptic inputs to a single neuron. In pursuing this goal, we observed patterns in the recordings that appeared to repeat with remarkable precision. Whether this finding is evidence that the cortex can produce precisely repeating patterns is a matter of contention, and we describe recent investigations of this question.
KeywordsSingle Neuron Synaptic Input Intracellular Recording Detector Window Putative Repeat
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