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Metastatic Orbital Tumors

  • Syed Mehdi AhmadEmail author
  • Bita Esmaeli
Chapter
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA, volume 6)

Abstract

Orbital metastasis is uncommon, accounting for only 1–13% of all orbital tumors reported. The approach to metastatic orbital tumors has dramatically changed in recent decades. The improved life expectancy of patients with common cancers, such as breast cancer and prostate cancer, together with aging of the population and the resultant increase in the number of patients at risk for cancer, has led to a higher incidence of patients living with metastatic disease in unusual sites such as the orbit. Furthermore, vigilant surveillance and advances in diagnostic testing have led to increased detection of orbital metastases. Because of the poor prognosis for patients with metastatic orbital disease, treatment is usually palliative and may include radiotherapy, chemotherapy, hormonal therapy, surgery, or a combination of these modalities. The ophthalmologist may play a pivotal role in the detection and management of these lesions in patients with and without a primary cancer diagnosis.

Keywords

Carcinoid Tumor Cutaneous Melanoma Extraocular Muscle Metastatic Prostate Cancer Orbital Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Shields CL, Shields JA, Gross N, et al. Survey of 520 uveal metastases. Ophthalmology 1997;104:1265–76.PubMedGoogle Scholar
  2. 2.
    Ahmad SM, Esmaeli B. Metastatic tumors of the orbit and ocular adnexa. Curr Opin Ophthalmol 2007;18:405–13.PubMedCrossRefGoogle Scholar
  3. 3.
    Goldberg RA, Rootman J, Cline R. Tumors metastatic to the orbit: a changing picture. Surv Ophthalmol 1990;35:1–24.PubMedCrossRefGoogle Scholar
  4. 4.
    Garrity JA, Henderson JW, Cameron JD, et al. Metastatic carcinomas. In: Henderson’s Orbital Tumors, fourth edition. New York, NY: Raven Press, 2007:313–26.Google Scholar
  5. 5.
    Char DH, Miller T, Kroll S. Orbital metastasis: diagnosis and course. Br J Ophthalmol 1997;81:386–90.PubMedCrossRefGoogle Scholar
  6. 6.
    Fenton S, Kemp SE, Harnett AN. Screening for ophthalmic involvement in asymptomatic patients with metastatic breast carcinoma. Eye 2004;18:38–40.PubMedCrossRefGoogle Scholar
  7. 7.
    Ferry AP. Tumors metastatic to the eye and ocular adnexa. In: Jakobiec FA, editor. Ocular and Adnexal Tumors. Birmingham, AL: Aesculapius, 1978:862–92.Google Scholar
  8. 8.
    Shields JA, Shields CL, Brotman HK, et al. Cancer metastatic to the orbit: the 2000 Robert M. Curtis lecture. Ophthal Plast Reconstr Surg 2001;17:346–54.PubMedCrossRefGoogle Scholar
  9. 9.
    Goldberg RA, Rootman J. Clinical characteristics of metastatic orbital tumors. Ophthalmology 1990;97:620–4.PubMedGoogle Scholar
  10. 10.
    Hart WM. Metastatic carcinoma to the eye and orbit. Int Ophthalmol Clin 1962;2:465–82.CrossRefGoogle Scholar
  11. 11.
    Castro PA, Albert DM, Wang WJ, et al. Tumors metastatic to the eye and adnexa. Int Ophthalmol Clin 1982;22:189–223.PubMedCrossRefGoogle Scholar
  12. 12.
    Font RL, Ferry AP. Carcinoma metastatic to the eye and orbit. III. A clinicopathologic case of 28 cases metastatic to the orbit. Cancer 1976;38:1326–35.PubMedCrossRefGoogle Scholar
  13. 13.
    Gunalp I, Gunduz K. Metastatic orbital tumors. Jpn J Ophthalmol 1995;39:65–70.PubMedGoogle Scholar
  14. 14.
    Hartstein ME, Beisman B, Kincaid MC. Cutaneous malignant melanoma metastatic to the eyelid. Ophthalmic Surg Lasers Imaging 1998;29:993–5.Google Scholar
  15. 15.
    Zografos L, Ducrey N, Beati D, et al. Metastatic melanoma in the eye and orbit. Ophthalmology 2003;110:2245–56.PubMedCrossRefGoogle Scholar
  16. 16.
    Esmaeli B, Cleary KL, Ho L, et al. Leiomyosarcoma of the esophagus metastatic to the eyelid: a clinicopathologic report. Ophthal Plast Reconstr Surg 2002;18:159–61.PubMedCrossRefGoogle Scholar
  17. 17.
    Liu D. Complications of fine needle aspiration biopsy of the orbit. Ophthalmology 1985;92:1768–71.PubMedGoogle Scholar
  18. 18.
    Arora R, Rewari R, Betharia SM. Fine needle aspiration cytology of orbital and adnexal masses. Acta Cytol 1992;36:483–91.PubMedGoogle Scholar
  19. 19.
    Kennerdell JS, Dekker A, Johnson SL, et al. Fine needle aspiration: its use in orbital tumors. Arch Ophthalmol 1979;97:1315–17.PubMedCrossRefGoogle Scholar
  20. 20.
    Capone A Jr, Slamovits TL. Discrete metastases of solid tumors to extraocular muscles. Arch Ophthalmol 1990;108:237–43.PubMedCrossRefGoogle Scholar
  21. 21.
    Glassburn JR, Klionsky M, Brady LW. Radiation therapy for metastatic disease involving the orbit. Am J Clin Oncol 1984;7:145–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Ahmed S, Goel S, Khandwala M, et al. Neuroblastoma with orbital metastasis: ophthalmic presentation and role of ophthalmologists. Eye 2006;20:466–70.PubMedCrossRefGoogle Scholar
  23. 23.
    Dieing A, Schulz CO, Schmid P, et al. Orbital metastases in breast cancer: report of two cases and review of the literature. J Cancer Res Clin Oncol 2004;130:745–48.PubMedCrossRefGoogle Scholar
  24. 24.
    Torres JJ, Medel R, Alonso T. Orbital metastases from male breast cancer in two cases. Ophthal Plast Reconstr Surg 2007;23:154–6.PubMedCrossRefGoogle Scholar
  25. 25.
    Macedo JE, Machado M, Araujo A, et al. Orbital metastasis as a rare form of clinical presentation of non-small cell lung cancer. J Thorac Oncol 2007;2:166–7.PubMedCrossRefGoogle Scholar
  26. 26.
    Boldt HC, Nerad JA. Orbital metastases from prostate carcinoma. Arch Ophthalmol 1988;106:1403–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Carriere VM, Karcioglu ZA, Apple DJ, et al. A review of prostate carcinoma with bilateral metastasis and a review of the literature. Ophthalmology 1982;89:402–6.PubMedGoogle Scholar
  28. 28.
    Hutchison BM, Damato BE, Kyle PM, et al. Choroidal melanoma metastatic to the contralateral orbit. Orbit 1994;13:85–9.CrossRefGoogle Scholar
  29. 29.
    Ramirez R, Ivan D, Prieto VG, et al. Cutaneous melanoma metastatic to the eyelid and periocular skin. Ophthal Plast Reconstr Surg. 2010;26:88–94.Google Scholar
  30. 30.
    Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003;97:934–59.PubMedCrossRefGoogle Scholar
  31. 31.
    Mehta JS, Abou-Rayyah Y, Rose GE. Orbital carcinoid metastases. Ophthalmology 2006;113:466–72.PubMedCrossRefGoogle Scholar
  32. 32.
    Amemiya T, Hayashida H, Dake Y. Metastatic orbital tumors in Japan: a review of the literature. Ophthalmic Epidemiol 2002;9:35–47.PubMedCrossRefGoogle Scholar
  33. 33.
    Shome D, Honavar SG, Gupta P, et al. Metastasis to the eye and orbit from renal cell carcinoma: a report of three cases and review of literature. Surv Ophthalmol 2007;52:213–23.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of OphthalmologyBaylor University Medical Center at DallasDallasUSA
  2. 2.Section of Ophthalmology, Department of Head and Neck SurgeryThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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