Organization of Motor Cortical Inputs to the Subthalamic Nucleus in the Monkey

  • Hirokazu Iwamuro
  • Yoshihisa Tachibana
  • Nobuhito Saito
  • Atsushi Nambu
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 58)


To investigate the motor cortical inputs to the subthalamic nucleus (STN), we examined the responses of STN neurons to electrical stimulation of the primary motor cortex (MI) and the supplementary motor area (SMA). Stimulating electrodes were chronically implanted in the orofacial, forelimb, and hindlimb regions of the MI, and the forelimb and hindlimb regions of the SMA in a macaque monkey. Cortical stimulation induced a neuronal response composed of an early excitation and a late excitation in the STN. Of the STN neurons with cortical inputs, approximately 70% responded exclusively to either MI- or SMA-stimulation and the remaining 30% responded to both MI- and SMA-stimulation. Neurons responding mainly to MI-stimulation were distributed in the dorsolateral part of the STN, while neurons responding mainly to SMA-stimulation were mainly present in the ventromedial region. Approximately 60% of STN neurons received inputs from a single somatotopical region, while the others received convergent inputs from multiple somatotopical regions. In the MI domain of the STN, neurons responding to the stimulation of the orofacial, forelimb, and hindlimb regions were represented in its lateral-most, central and medial parts, respectively. In the SMA domain, neurons receiving inputs from the forelimb region were located more medially than those receiving inputs from the hindlimb region. The present study has clearly demonstrated that the STN is somatotopically organized based on the cortical inputs from the MI and SMA despite considerable convergence.


Supplementary Motor Area Cortical Stimulation Cortical Input Late Excitation Somatotopical Organization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Albin RL, Young AB and Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12: 366–375.CrossRefPubMedGoogle Scholar
  2. Alexander GE and Crutcher MD (1990) Functional architecture of basal ganglia circuits: Neural substrates of parallel processing. Trends Neurosci 13: 266–271.CrossRefPubMedGoogle Scholar
  3. Alexander GE, DeLong MR and Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci 9: 357–381.CrossRefPubMedGoogle Scholar
  4. Bevan MD, Magill PJ, Hallworth NE, Bolam JP and Wilson CJ (2002) Regulation of the timing and pattern of action potential generation in rat subthalamic neurons in vitro by GABA-A IPSPs. J Neurophysiol 87: 1348–1362.PubMedGoogle Scholar
  5. DeLong MR, Crutcher MD and Georgopoulos AP (1985) Primate globus pallidus and subthalamic nucleus: Functional organization. J Neurophysiol 53: 530–543.PubMedGoogle Scholar
  6. Fujimoto K and Kita H (1993) Response characteristics of subthalamic neurons to the stimulation of the sensorimotor cortex in the rat. Brain Res 609: 185–192.CrossRefPubMedGoogle Scholar
  7. Kita H, Chang HT and Kitai ST (1983) The morphology of the intracellular labeled rat subthalamic neurons: A light microscopic analysis. J Comp Neurol 215: 245–257.CrossRefPubMedGoogle Scholar
  8. Kitai ST and Deniau JM (1981) Cortical inputs to the subthalamus: Intracellular analysis. Brain Res 214: 411–415.CrossRefPubMedGoogle Scholar
  9. Levy R, Hazrati L-N, Herrero M-T, Vila M, Hassani O-K, Mouroux M, Ruberg M, Asensi H, Agid Y, Féger J, Obeso JA, Parent A and Hirsch EC (1997) Re-evaluation of the functional anatomy of the basal ganglia in normal and parkinsonian states. Neuroscience 76: 335–343.CrossRefPubMedGoogle Scholar
  10. Matsumura M, Kojima J, Gardiner TW and Hikosaka O (1992) Visual and oculomotor functions of monkey subthalamic nucleus. J Neurophysiol 67: 1615–1632.PubMedGoogle Scholar
  11. Maurice N, Deniau JM, Glowinski J and Thierry AM (1998) Relationships between the prefrontal cortex and the basal ganglia in the rat: Physiology of the corticosubthalamic circuits. J Neurosci 18: 9539–9546.PubMedGoogle Scholar
  12. Mink JW (1996) The basal ganglia: Focused selection and inhibition of competing motor programs. Prog Neurobiol 50: 381–425.CrossRefPubMedGoogle Scholar
  13. Mink JW and Thach WT (1993) Basal ganglia intrinsic circuits and their role in behavior. Curr Opin Neurobiol 3: 950–957.CrossRefPubMedGoogle Scholar
  14. Miyachi S, Lu X, Imanishi M, Sawada K, Nambu A, Takada M (2006) Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex. Neurosci Res 56: 300–308.CrossRefPubMedGoogle Scholar
  15. Monakow KH, Akert K and Künzle H (1978) Projections of the precentral motor cortex and other cortical areas of the frontal lobe to the subthalamic nucleus in the monkey. Exp Brain Res 33: 395–403.CrossRefPubMedGoogle Scholar
  16. Nakanishi H, Kita H and Kitai ST (1987) Electrical membrane properties of rat subthalamic neurons in an in vitro slice preparation. Brain Res 437: 35–44.CrossRefPubMedGoogle Scholar
  17. Nambu A, Takada M, Inase M and Tokuno H (1996) Dual somatotopical representations in the primate subthalamic nucleus: Evidence for ordered but reversed body-map transformations from the primary motor cortex and the supplementary motor area. J Neurosci 16: 2671–2683.PubMedGoogle Scholar
  18. Nambu A, Tokuno H, Hamada I, Kita H, Imanishi M, Akazawa T, Ikeuchi Y and Hasegawa N (2000) Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey. J Neurophysiol 84: 289–300.PubMedGoogle Scholar
  19. Nambu A, Kaneda K, Tokuno H and Takada M (2002a) Organization of corticostriatal motor inputs in monkey putamen. J Neurophysiol 88: 1830–1842.PubMedGoogle Scholar
  20. Nambu A, Kita H, Akazawa T, Imanishi M and Takada M (2002b) Excitatory cortical input to the subthalamic nucleus through the cortico-striato-external pallido-subthalamic ‘indirect’ pathway. Abstr 32nd Ann Meeting Soc f Neurosci 358.10.Google Scholar
  21. Nambu A, Tokuno H and Takada M (2002c) Functional significance of the cortico-subthalamo-pallidal ‘hyperdirect’ pathway. Neurosci Res 43: 111–117.CrossRefPubMedGoogle Scholar
  22. Ryan LJ, Clark KB (1992) Alteration of neural responses in the subthalamic nucleus following globus pallidus and neostriatal lesions in rats. Brain Res Bull 29: 319–327.CrossRefPubMedGoogle Scholar
  23. Wichmann T, Bergman H and DeLong MR (1994) The primate subthalamic nucleus. I. Functional properties in intact animals. J Neurophysiol 72: 494–506.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Hirokazu Iwamuro
    • 1
  • Yoshihisa Tachibana
    • 1
  • Nobuhito Saito
    • 2
  • Atsushi Nambu
    • 1
  1. 1.Division of System NeurophysiologyNational Institute for Physiological SciencesMyodaijiJapan
  2. 2.Department of NeurosurgeryThe University of TokyoBunkyo-kuJapan

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