Advertisement

The Subthalamic Region of Luys, Forel, and Dejerine

  • John S. McKenzie
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 58)

Abstract

The subthalamic region (ST) embraces the subthalamic nucleus (STN), zona incerta (ZI), Forel’s fields (H, H1 and H2), and their nucleus (FF). JB Luys of Paris first described STN in human brain atlases, in 1865 as drawings and in 1873 in photographs of brain slices. He completely ignored ZI and Forel’s fields. As an industrious neurologist and neuropathologist, he treated many mental patients by hypnosis. In his later public demonstrations, he neglected proper scientific controls, and was duped by collusive patients to believe in bizarre sensory properties and symptom transfer. In 1877 Forel produced the first adequate description of ST, in serial sections. He later specialised in neurology and psychiatry, directing the Zurich mental asylum. In combatting alcoholism as a cause of insanity he adopted the strategy of total abstinence. He was renowned also for his scientific work on ants. Dejerine and his wife Augusta Klumpke were an outstanding neurological team in Paris. In their great two-volume work on the anatomy of nervous centres, they established the detailed structure of ST, still largely accepted. Their devoted neurological work with the war wounded soldiers led to the exhausted Dejerine’s death in 1917. His widow continued the work until her death in 1927.

Keywords

Grey Matter Substantia Nigra Deep Brain Stimulation Chromic Acid Superior Cerebellar Peduncle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. André-Thomas (1928) Necrologie. Augusta Dejerine-Klumpke (1859–1927). L’Encéphale 23: 75–88.Google Scholar
  2. Beaudoin M (1897) Necrologie, M le Dr Luys. Le Progrès Méd 2: 141–142.Google Scholar
  3. Cadet de Gassicourt E (1897) Osèques de M le Dr Luys. Bull Acad Med 38: 198–200.Google Scholar
  4. Dejerine J (1895–1901) Anatomie des centres nerveux. Rueff, Paris.Google Scholar
  5. Forel A (1877) Untersuchungen uber die Haubenregion und ihre oberen verknupfungen im Gehirne des Menschen. Arch f Psychiat 7: 393–495.CrossRefGoogle Scholar
  6. Forel A (1937) Out of my life and work (trans. B Miall). George Allen & Unwin, London.Google Scholar
  7. Forel A (1968) August Forel, Briefe correspondance 1849–1927. Hans Hube, Bern.Google Scholar
  8. Kuhlenbeck A (1953) August Forel (1848–1931). In Haymaker W (ed.) The founders of neurology. CC Thomas, New York, NY.Google Scholar
  9. Luys J (1865) Recherches sur le système nerveux cérébro-spinal. Baillière, Paris.Google Scholar
  10. Luys J (1873) Iconographie photographique du système nerveux. Baillière, Paris.Google Scholar
  11. Luys J (1886) Description d’une nouvelle region de substance grise… L’Encéphale 6: 5–10.Google Scholar
  12. Luys J (1889) The brain and its functions, 3rd ed. Kegan, Paul, Trench, London.Google Scholar
  13. Luys J (1892a) Des procédés à employer pour l’étude anatomique et photographique du système nerveux. Ann Psychiat Hypnol 2: 129–141.Google Scholar
  14. Luys J (1892b) De la visibilité, par les sujets en etat hypnotique, des effluves dégagés par les êtres vivants. C R Soc Biol Paris, séance 18 juillet 1892: 657–659.Google Scholar
  15. Luys J (1893) De la visibilité directe des effluves cérébraux. C R Soc Biol Paris, séance 17 juin 1893: 638–641.Google Scholar
  16. Luys (1894) De l’emmagasinement de certaines activités cerebrales dans une couronne aimantée. C R Soc Biol Paris, séance 10 février 1894: 128–130.Google Scholar
  17. Luys et David (1897a) Note sur l’enregistrement photographique des effluves qui se dégagent des extrémités des doigts et du fond de l’oeil de l’être vivant… C R Soc Biol Paris, séance 29 mai 1897: 515–519.Google Scholar
  18. Luys et David (1897b) Fixation par la photographie des effluves qui se dégagent de l’appareil auditif… C R Soc Biol Paris, séance 10 juillet 1897: 676–678.Google Scholar
  19. Mai JK, Assheuer J, Paxinos G (1997) Atlas of the human brain. Academic, London.Google Scholar
  20. Meyer A (1971) Historical aspects of cerebral anatomy. Oxford University Press, London.Google Scholar
  21. Meyer Ad (1893) Neurologists and neurological laboratories. II Neurological work at Zurich. J Comp Neurol 3: 1–6.CrossRefGoogle Scholar
  22. Parent A (2002) Jules Bernard Luys and the subthalamic nucleus. Mov Disord 17: 181–185.CrossRefPubMedGoogle Scholar
  23. Parent A, Parent M, Leroux-Hugon V (2002) Jules Bernard Luys: A singular figure in 19th century neurology. Can J Neurol Sci 29: 282–288.PubMedGoogle Scholar
  24. Plaha P, Ben-Shlomo Y, Patel NK, et al (2006) Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain 129: 1732–1747.CrossRefPubMedGoogle Scholar
  25. Ritti A (1897) Necrologie: Dr J Luys. Ann Médicopsych 6: 321–323.Google Scholar
  26. Semelaigne R (1930–1932) Les pionniers de la psychiatrie française: avant et après Pinel. Baillière, Paris.Google Scholar
  27. Zabriskie E G (1953) Joseph Jules Dejerine (1849–1917). In Haymaker W (ed) Op cit.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of PhysiologyThe University of MelbourneMelbourneAustralia

Personalised recommendations