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Basal Ganglia and Behaviour: Behavioural Effects of Deep Brain Stimulation in Experimental Neurological and Psychiatric Disorders

  • Thibault Sesia
  • Sonny Tan
  • Rinske Vlamings
  • Lee Wei Lim
  • Veerle Visser-Vandewalle
  • Yasin Temel
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 58)

Abstract

The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the same clinical effects as a lesion with respect to the improvement of clinical disability, but has more advantages such as its adjustability and reversibility. To this day, fundamental knowledge regarding the application of electrical currents to deep brain structures is far from complete. Despite improving key symptoms in movement disorders, DBS can be associated with the occurrence of a variety of changes in cognitive and limbic functions both in humans and animals. Furthermore, in psychiatric disorders, DBS is primarily used to evoke cognitive and limbic changes to reduce the psychiatric disability. Preclinical DBS experiments have been carried out to investigate the mechanisms underlying the clinical effects of DBS for at least three (interrelated) reasons: to increase our scientific knowledge, to optimize/refine the technology, or to prevent/reduce side effects. In this review, we will discuss the behavioural effects of DBS in experimental neurological and psychiatric disorders.

Keywords

Deep Brain Stimulation Obsessive Compulsive Disorder Obsessive Compulsive Disorder Symptom Spontaneous Alternation Behaviour Basal Ganglion Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The deep brain stimulation program of Yasin Temel and colleagues received support from the Dutch Medical Research Council (ZonMw and NWO), the Dutch Brain Foundation (Hersenstichting Nederland), the Prinses Beatrix Foundation, and the FP6 Marie Curie Fellowship (MEST-CT-2005-020589).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Thibault Sesia
    • 1
  • Sonny Tan
    • 1
  • Rinske Vlamings
    • 1
  • Lee Wei Lim
    • 1
  • Veerle Visser-Vandewalle
    • 1
  • Yasin Temel
    • 1
  1. 1.Department of NeurosurgeryUniversity Hospital MaastrichtMaastrichtThe Netherlands

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