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Basal Ganglia and Behaviour: Behavioural Effects of Deep Brain Stimulation in Experimental Neurological and Psychiatric Disorders

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The Basal Ganglia IX

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 58))

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Abstract

The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the same clinical effects as a lesion with respect to the improvement of clinical disability, but has more advantages such as its adjustability and reversibility. To this day, fundamental knowledge regarding the application of electrical currents to deep brain structures is far from complete. Despite improving key symptoms in movement disorders, DBS can be associated with the occurrence of a variety of changes in cognitive and limbic functions both in humans and animals. Furthermore, in psychiatric disorders, DBS is primarily used to evoke cognitive and limbic changes to reduce the psychiatric disability. Preclinical DBS experiments have been carried out to investigate the mechanisms underlying the clinical effects of DBS for at least three (interrelated) reasons: to increase our scientific knowledge, to optimize/refine the technology, or to prevent/reduce side effects. In this review, we will discuss the behavioural effects of DBS in experimental neurological and psychiatric disorders.

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Acknowledgements

The deep brain stimulation program of Yasin Temel and colleagues received support from the Dutch Medical Research Council (ZonMw and NWO), the Dutch Brain Foundation (Hersenstichting Nederland), the Prinses Beatrix Foundation, and the FP6 Marie Curie Fellowship (MEST-CT-2005-020589).

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Authors and Affiliations

  1. Department of Neurosurgery, University Hospital Maastricht, P. Debyelaan 25, 6202, AZ, Maastricht, The Netherlands

    Thibault Sesia, Sonny Tan, Rinske Vlamings, Lee Wei Lim, Veerle Visser-Vandewalle & Yasin Temel

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  1. Thibault Sesia
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  2. Sonny Tan
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  3. Rinske Vlamings
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  4. Lee Wei Lim
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  5. Veerle Visser-Vandewalle
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  6. Yasin Temel
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Correspondence to Yasin Temel .

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Editors and Affiliations

  1. Dept. Anatomy & Neurosciences, Vrije Universiteit Amsterdam, Amsterdam, 1007 MB, Netherlands

    Hendrik Jan Groenewegen

  2. Medical Center, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam, 1081 BT, Netherlands

    Pieter Voorn

  3. Department of Neurology, Vrije Universiteit Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, Netherlands

    Henk W. Berendse

  4. Medical Center, Vrije Universiteit, Van der Boechorststraat 7, Amsterdam, 1081 BT, Netherlands

    Antonius B. Mulder

  5. Medical Centre, Radboud University Nijmegen, Geert Grooteplein 21a, Nijmegen, 6525 EZ, Netherlands

    Alexander R. Cools

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Sesia, T., Tan, S., Vlamings, R., Lim, L.W., Visser-Vandewalle, V., Temel, Y. (2009). Basal Ganglia and Behaviour: Behavioural Effects of Deep Brain Stimulation in Experimental Neurological and Psychiatric Disorders. In: Groenewegen, H., Voorn, P., Berendse, H., Mulder, A., Cools, A. (eds) The Basal Ganglia IX. Advances in Behavioral Biology, vol 58. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0340-2_36

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