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Information Processing in the Striatum of Behaving Monkeys

  • Atsushi Nambu
  • Nobuhiko Hatanaka
  • Sayuki Takara
  • Yoshihisa Tachibana
  • Masahiko Takada
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 58)

Abstract

Neuronal signals in the cerebral cortex are sent to the striatum, which is a major input structure of the basal ganglia. The striatum contains GABAergic spiny projection neurons and interneurons. Projection neurons, which receive excitatory glutamatergic inputs from the cortex and thalamus through both NMDA and AMPA/kainate receptors, have extensive local axon collaterals that form synapses with other neighboring projection neurons. GABAergic interneurons receive cortical inputs and innervate projection neurons. Thus, the activity of projection neurons is thought to be controlled by such GABAergic networks in the striatum. To investigate the functions of GABAergic networks, we recorded the activity of striatal projection neurons in behaving monkeys during performance of a reaching task with delay under the blockade of GABAergic and glutamatergic neurotransmission. Injection of a GABAA receptor blocker, gabazine, in the vicinity of the recorded neurons enhanced cortically evoked responses and task-related activity. Additional injection of glutamatergic blockers (a mixture of an NMDA receptor blocker, CPP and an AMPA/kainate receptor blocker, NBQX) diminished both cortically evoked responses and task-related activity to almost zero. These results suggest that the activity of striatal projection neurons is (1) mainly governed by the cortical inputs and (2) modified or adjusted by GABAergic networks in the striatum.

Keywords

Projection Neuron GABAergic Interneuron Medium Spiny Neuron Cortical Input Feedforward Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Atsushi Nambu
    • 1
  • Nobuhiko Hatanaka
    • 1
  • Sayuki Takara
    • 1
  • Yoshihisa Tachibana
    • 1
  • Masahiko Takada
    • 2
  1. 1.Division of System NeurophysiologyNational Institute for Physiological SciencesOkazakiJapan
  2. 2.Systems Neuroscience SectionPrimate Research Institute, Kyoto UniversityInuyamaJapan

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