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A Subpopulation of Mesencephalic Dopamine Neurons Interfaces the Shell of Nucleus Accumbens and the Dorsolateral Striatum in Rats

  • Yvette C. van Dongen
  • Bogdan P. Kolomiets
  • Henk J. Groenewegen
  • Anne-Marie Thierry
  • Jean-Michel Deniau
Conference paper
Part of the Advances in Behavioral Biology book series (ABBI, volume 58)

Abstract

Nigrostriatal dopaminergic neurons are usually considered to interface the ventral limbic and dorsal sensorimotor striatum, since the shell of the nucleus accumbens (Acb shell) projects to the ventral tegmental area/substantia nigra pars compacta (VTA/SNC) complex. However, both the organization of Acb shell projections to the nigrostriatal neurons innervating the sensorimotor striatum and the synaptic influence exerted by the Acb shell on these neurons remain to be determined. These questions were addressed in the rat using neuroanatomical and electrophysiological approaches.

Combined anterograde tracing from the Acb shell with retrograde tracing from the sensorimotor region of the dorsal striatum revealed that labeled fibers from the Acb shell overlap retrogradely labeled nigrostriatal neurons located in the medial SNC and the lateral VTA but avoid the nigrostriatal neurons located laterally. In addition, stimulation of the Acb-shell induced an inhibition of dopaminergic nigrostriatal neurons projecting to the sensorimotor striatal territory. In agreement with the anatomical observations, these responses were observed in nigrostriatal neurons located in the medial SNC and the lateral VTA but not in nigrostriatal neurons located laterally.

These data further establish the existence of a functional link between the Acb shell and the sensorimotor striatum via dopaminergic nigrostriatal neurons. The present study also reveals that among the dopaminergic nigrostriatal neurons innervating the sensorimotor striatal territory, only the subpopulation located in the medial SNC and lateral VTA receives an inhibitory input from the Acb shell. This indicates a functional heterogeneity within the population of dopaminergic neurons innervating a given striatal territory.

Keywords

Ventral Striatum Dorsal Striatum Nigrostriatal Neuron Dorsolateral Striatum Anterograde Tracer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Supported by a Dutch Medical Research Council program grant (NWO-ZonMW 903-42-092) and a NWO-ZonMW/INSERM travel grant (910-48-029).

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Yvette C. van Dongen
    • 1
  • Bogdan P. Kolomiets
    • 1
  • Henk J. Groenewegen
    • 1
  • Anne-Marie Thierry
    • 1
  • Jean-Michel Deniau
    • 1
  1. 1.Institut National de la Santé et de la Recherche Médicale U 114Chaire de Neuropharmacologie, Collège de FranceParis CedexFrance

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