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Axon Guidance in the Dopamine System

  • Chapter
Book cover Development and Engineering of Dopamine Neurons

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 651))

Abstract

Meso-diencephalic dopamine neurons (mdDA) neurons are located in the retrorubral field (RRF), substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and give rise to prominent ascending axon projections. These so-called mesotelencephalic projections are organized into three main pathways: the mesostriatal, mesocortical and mesolimbic pathways. Mesotelencephalic pathways in the adult nervous system have been studied in much detail as a result of their important physiological functions and their implication in psychiatric, neurological and neurodegenerative disease. In comparison, relatively little is known about the formation of these projection systems during embryonic and postnatal development. However, understanding the formation of mdDA neurons and their projections is essential for the design of effective therapies for mdDA neuron-associated neurological and neurodegenerative disorders. Here we summarize our current knowledge of the ontogeny of mdDA axon projections in subsystems of the developing rodent central nervous system (CNS) and discuss the cellular and molecular mechanisms that mediate mdDA axon guidance in these CNS regions.

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Authors and Affiliations

  1. Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands

    Asheeta A. Prasad & R. Jeroen Pasterkamp

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  1. Asheeta A. Prasad
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  2. R. Jeroen Pasterkamp
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Correspondence to R. Jeroen Pasterkamp .

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  1. Rudolf Magnus Institute of Neuroscience Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands

    R. Jeroen Pasterkamp PhD , Marten P. Smidt PhD  & J. Peter H. Burbach PhD ,  & 

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Prasad, A.A., Pasterkamp, R.J. (2009). Axon Guidance in the Dopamine System. In: Pasterkamp, R.J., Smidt, M.P., Burbach, J.P.H. (eds) Development and Engineering of Dopamine Neurons. Advances in Experimental Medicine and Biology, vol 651. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0322-8_9

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