TGF-β in Dopamine Neuron Development, Maintenance and Neuroprotection

  • Eleni Roussa
  • Oliver von Bohlen und Halback
  • Kerstin Krieglstein
Part of the Advances in Experimental Medicine and Biology book series (volume 651)


Transforming growth factor betas (TGF-βs) are multifunctional cytokines with widespread distribution. In the nervous system the biological effects of TGF-β cover regulation of proliferation, migration, differentiation, survival and death. Specifically, the effects of TGF-β on mesencephalic DAergic neurons extend from induction and specification of the dopaminergic phenotype via promotion of survival to neuroprotection in animal models of parkinsonism. Experimental in vitro and in vivo models have contributed to a better understanding of the putative mechanisms underlying the effects of TGF-β on DAergic neurons and unravelled synergisms between members of the TGF-β superfamily. In this chapter, we will review the literature available with focus on TGF-β proper and glial cell-line-derived neurotrophic factor (GDNF).


Dopaminergic Neuron Ventral Mesencephalon DAergic Neuron Midbrain Dopaminergic Neuron Midbrain Dopamine Neuron 


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Eleni Roussa
    • 1
    • 2
  • Oliver von Bohlen und Halback
    • 1
    • 2
  • Kerstin Krieglstein
    • 1
  1. 1.Institute for Anatomy and Cell Biology, Department of Molecular EmbryologyUniversity of FreiburgFreiburgGermany
  2. 2.Interdisciplinary Center for Neurosciences NeuroanatomyUniversity of HeidelbergHeidelbergGermany

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