The Role of Otx Genes in Progenitor Domains of Ventral Midbrain

  • Antonio Simeone
  • Eduardo Puelles
  • Dario Acampora
  • Daniela Omodei
  • Pietro Mancuso
  • Luca Giovanni Di Giovannantonio
Part of the Advances in Experimental Medicine and Biology book series (volume 651)


The mesencephalic dopaminergic (mesDA) neurons play a relevant role in the control of movement, behaviour and cognition. Indeed loss and/or abnormal development of mesDA neurons is responsible for Parkinson’s disease as well as for addictive and psychiatric disorders. A wealth of information has been provided on gene functions involved in the molecular mechanism controlling identity, fate and survival of mesDA neurons. Collectively, these studies are contributing to a growing knowledge of the genetic networks required for proper mesDA development, thus disclosing new perspectives for therapeutic approaches of mesDA disorders. Here we will focus on the control exerted by Otx genes in early decisions regulating the differentiation of progenitors located in the ventral midbrain. In this context, the regulatory network involving Otx functional interactions with signalling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail.


Ventral Midbrain Conditional Mutant Progenitor Domain Molecular Code Ventral Neural Tube 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Antonio Simeone
    • 1
    • 2
  • Eduardo Puelles
    • 3
  • Dario Acampora
    • 1
    • 2
  • Daniela Omodei
    • 1
  • Pietro Mancuso
    • 1
  • Luca Giovanni Di Giovannantonio
    • 1
  1. 1.CEINGE Biotecnologie Avanzate and SEMM European School of Molecular MedicineNaplesItaly
  2. 2.Institute of Genetics and BiophysicsNaplesItaly
  3. 3.Instituto de Neurociencias de AlicanteCSIC and Universidad Miguel HernàndezSant Joan d’AlacantSpain

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