Biomarkers in Spondyloarthropathies

  • Chun-Hsiung Chen
  • David Tak Yan Yu
  • Chung-Tei Chou
Part of the Advances in Experimental Medicine and Biology book series (volume 649)


The study of biomarkers in spondyloarthropathy (SpA) has emerged to be a very important field of research. This is particularly because the two commonly used biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), are of very low sensitivity and specificity. The second reason is, with advances in the treatment of SpA by the very expensive tumor necrosis factor-α (TNF-α) blockers, for cost-effectiveness, clinicians need to be much more accurate in predicting disease progression, evaluating disease activity and monitoring therapeutic efficacy. This review focuses on several biomarkers of promise: matrix metalloproteinases 3 (MMP-3), Type II collagen neoepitope (C2C and C1-2C), C-propeptide of Type II collagen (CPII), aggrecan 846 epitope, macrophage colony stimulating factor (M-CSF), serum amyloid A (SAA) and Interleukin-6 (IL-6). The results summarized in Table 1 call for a co-ordinated effort for systematic studies of existing biomarkers and for search for new candidates.


Ankylose Spondylits Bath Ankylose Spondylitis Functional Index Cartilage Oligomeric Matrix Protein BASDAI Score Bath Ankylose Spondylitis Patient Global 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  • Chun-Hsiung Chen
    • 1
  • David Tak Yan Yu
    • 2
  • Chung-Tei Chou
    • 3
  1. 1.Institute of Clinical MedicineNational Yang-Ming University and Veterans General HospitalTaipeiTaiwan
  2. 2.Rheumatology Division Rehabilitation CenterUniversity of CaliforniaLos AngelesUSA
  3. 3.Division of Allergy, Immunology and RheumatologyVeterans General HospitalTaipeiTaiwan

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